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US 2006/0223189 A1Published application
Solid-phase saccharide sensing compounds
AssigneeTerumo Kabushiki Kaisha
InventorsTetsuro Kawanishi, Mathew Romey, Mark Holody, Peter Zhu, Seiji Shinkai
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Abstract
The present invention provides solid-phase saccharide dyes. The dyes are bisboronic acids covalently bonded to a solid substrate. The dyes selectively conjugate with saccharides, particularly glucose, and register a signal. The signal is proportional to the quantity of saccharide. Thus, the dyes of the present invention are useful for measuring and monitoring saccharide levels, particularly in biological fluids such as blood.
Claims25
A compound of the formula:
- where:
- Q is a fluorophore;
- R1, R2, and R3 are independently selected from the group consisting of linker arms and non-linker substituents;
- where the linker arm is a saturated or unsaturated, substituted or unsubstituted, hydrocarbon of about C30 or fewer, and is covalently bonded to a solid-phase material;
- where the non-linker substituent is hydrogen, or a saturated or unsaturated, substituted or unsubstituted, hydrocarbon of about C20 or fewer;
- and
- R4, R5, R6, and R7 are the same or different, and are selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, arylalkyl, substituted alkyl, acyl, alkyloxy, and halogen.
4 more elements
A compound of the formula:
- wherein:
- Q is a fluorophore;
- R1 and R2 are the same and are selected from the group consisting of carboxyalkyl and alkylamino substituents, and are covalently bound to a solid-phase support material;
- and
- R3 is selected from the group consisting of hydrogen, halogen, alkyl, acyl, alkyloxy, nitro, carboxylic acid, and carboxylic acid ester;
- and
- R4, R5, R6, and R7 are the same or different, and are selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, arylalkyl, acyl, alkyloxy, and halogen.
4 more elements
A compound of the formula:
- where:
- Q is anthracene;
- R1 and R2 are C1-C12 hydrocarbons covalently bonded to a solid-phase material;
- and
- R3 is acetyl;
- and
- R4 and R5, and R6 and R7 are either all H, or the two pairs respectively form a condensed aromatic ring structure.
4 more elements
A compound of the formula:
- wherein:
- Q is anthracene;
- R1 and R2 are non-linker hydrocarbons of C1-C12;
- R3 is an amide containing hydrocarbon linker arm covalently bonded to a polymeric solid-phase support;
- and
- R4 and R5, and R6 and R7 are either all H, or the two pairs respectively form a condensed aromatic ring structure.
3 more elements
Dependencies are inferred from the claim text.