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US 2006/0223182 A1Published application
Device for producing autologous VEGF
OwnerThomas DiMauro, Mohamed Attawia +1inventors
InventorsThomas DiMauro, Mohamed Attawia, Chantal Holy
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Abstract
A method of adding an effective amount of reactive oxygen species (ROS) to a mixture of macrophages to induce VEGF production by the macrophages. The induced macrophages are then added to a graft material.
Claims36
A method of enhancing tissue repair, comprising the steps of:
- a) providing a mixture of macrophages,
- b) contacting an effective amount of reactive oxygen species to the mixture to produce a formulation capable of inducing VEGF production in the macrophages, and
- c) placing the formulation in a patient.
A photocatalytic device for producing autologous VEGF, comprising:
- a. a chamber adapted to retain a mixture comprising macrophages,
- b. a photocatalytic layer within the chamber;
- c. a light source adapted to irradiate the photocatalytic layer, and
- d. an inducer capable of inducing VEGF production present within the chamber.
1 more element
A graft for tissue repair, comprising:
- a) viable cells, and
- b) macrophages induced to produce VEGF.
A method of enhancing tissue repair, comprising the steps of:
- a) providing a mixture of endothelial cells,
- b) contacting an effective amount of reactive oxygen species to the mixture to produce a formulation capable of inducing VEGF production in the macrophages, and
- c) placing the formulation in a patient.
Dependencies are inferred from the claim text.