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US 2006/0223176 A1Published application
Integrated system for on-site cell acquisition, processing, and delivery
AssigneeAbbott Cardiovascular Systems Inc.
InventorsEvgenia Mandrusov, Albert Chin, William Webler, Yan Shen, Robert Ainsworth, Eugene Michel
Life of this patent
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Abstract
Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.
Claims46
A method, comprising:
- extracting bone marrow from a patient;
- processing said bone marrow to isolate mononuclear cells within a closed system;
- and
- delivering said mononuclear cells back to said patient, wherein said extracting, processing, and delivering are continuous within a treatment period.
1 more element
A method, comprising:
- drawing a mixture comprising a density gradient solution, a washing solution, and the bone marrow extract into the first syringe coupled to a second syringe of a processing set configured to separate mononuclear cells from a bone marrow extract;
- spinning the first syringe to separate the mixture into a layer of mononuclear cells and a layer of waste fluid;
- passing the layer of mononuclear cells through a filter coupled to the first syringe and the second syringe to collect the mononuclear cells in the filter;
- drawing the washing solution through the filter and into the second syringe to wash out the mononuclear cells for collection of the mononuclear cells in the second syringe.
1 more element
A system, comprising;
- a cell processing device to separate mononuclear cells from a bone marrow extract, the cell processing device comprising a first syringe coupled to a second syringe and a rotating mechanism coupled to the first syringe;
- and
- a first container to provide a source of a gradient solution for the cell processing device and a second container to provide a source of a washing solution for the cell processing device, the first container and the second container coupled to the cell processing device with a network of tubes.
A cell processing system, comprising:
- means for drawing a mixture comprising a density gradient solution, a washing solution, and the bone marrow extract into the first syringe coupled to a second syringe of a processing set configured to separate mononuclear cells from a bone marrow extract;
- means for spinning the first syringe to separate the mixture into a layer of mononuclear cells and a layer of waste fluid;
- means passing the layer of mononuclear cells through a filter coupled to the first syringe and the second syringe to collect the mononuclear cells in the filter;
- means for drawing the washing solution through the filter and into the second syringe to wash out the mononuclear cells for collection of the mononuclear cells in the second syringe.
1 more element
Dependencies are inferred from the claim text.