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AssigneeThe Rockefeller University
InventorsFeng Liu, Angus Nairn, Paul Greengard
Estimating the term…
The present invention provides methods and compositions for modulating the activities of metabotropic glutamate receptor intracellular signaling molecules. The present invention provides methods and compositions for modulating the activities of casein kinase I and/or cyclin-dependent kinase 5 in cells or tissues. The present invention provides methods of modulating the function of calcium channels in cells or tissues. The present invention provides methods of treating calcium channel dysfunction. The present invention provides methods of identifying agents that modulate the activities of the metabotropic glutamate receptor intracellular signaling molecules casein kinase I and/or cyclin-dependent kinase 5 for use in such treatments.
-8. (canceled)
A method for modulating cyclin-dependent kinase 5 (“Cdk5”) activity in a cell or tissue comprising contacting the cell or tissue with an effective amount of a compound that alters the activity of phopholipase C-beta (“PLCβ”), wherein contact of the cell or tissue with the compound results in a modulation of Cdk5 activity.
-20. (canceled)
Dependencies are inferred from the claim text.