Enhancement of in vitro culture or vaccine production in bioreactors using electromagnetic energy
OwnerJackson Streeterinventor
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Abstract
Disclosed are apparatus and methods for enhancing or improving cell cultures, including cell cultures for the production of monoclonal antibodies, using electromagnetic energy treatment, primarily using electromagnetic radiation in the near infrared to visible region of the spectrum. The delivery of electromagnetic energy to a culture, in accordance with preferred embodiments, enhances or improves the cell culture such as by providing for enhanced and accelerated formation of important biological macromolecules, including, but not limited to, antibodies, proteins, collagen, and polysaccharides, and also providing for accelerated cellular replication and an enhancement or prolongation of the life of cells so treated.
Claims38
A bioreactor, comprising:
- a reservoir for holding a cell culture comprising cells and a culture medium;
- and
- an electromagnetic radiation source which irradiates the cells with electromagnetic radiation having a power density above about 1 mW/cm2 within a wavelength bandwidth of less than or equal to approximately 100 nanometers.
A method for enhancing the production of cells or cell-derived products from a bioreactor containing a cell culture, the method comprising delivering an effective amount of electromagnetic energy to cells in the cell culture, wherein delivering the effective amount of electromagnetic energy includes delivering electromagnetic radiation having a power density of at least about 1 mW/cm2 within a wavelength bandwidth of less than or equal to approximately 100 nanometers to the cells in the cell culture.
A method for enhancing the production of a vaccine from a bioreactor containing cells in a cell culture, the method comprising delivering an effective amount of electromagnetic energy to cells in the cell culture, wherein delivering the effective amount of electromagnetic energy includes delivering electromagnetic radiation having a power density of at least about 1 mW/cm2 within a wavelength bandwidth of less than or equal to approximately 100 nanometers.
Dependencies are inferred from the claim text.