Midecamycin hyper producing strain
AssigneeMeiji Seika Kaisha, Ltd.
InventorsManabu Watanabe, Masaaki Nakahashi
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Abstract
A midecamycin hyper producing strain having improved productivity of midecamycin which is a member of macrolide antibiotics, and a method for producing midecamycins using the strain are provided. The midecamycin producing actinomycetes comprises a midecamycin biosynthesis gene or a homologue thereof, wherein at least one module in a polyketide synthase gene of a midecamycin biosynthesis gene or partial sequences of the at least one module, is substituted so as to encode the corresponding amino acid sequences of the other module.
Claims10
A midecamycin producing actinomycetes comprising a midecamycin biosynthesis gene or a homologue thereof, wherein at least one module in a polyketide synthase gene of a midecamycin biosynthesis gene or partial sequences of the at least one module, is substituted so as to encode the corresponding amino acid sequences of the other module.
Dependencies are inferred from the claim text.