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US 2006/0223141 A1Published application
Transcription amplification system for molecular imaging
AssigneeThe Regents of the University of California The Office of the President
InventorsMichael Carey, Lily Wu, Sanjiv Gambhir, Meera Iyer, Joanne Zhang
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Abstract
The present invention provides a transcription amplification system, comprising an effector nucleic acid molecule and a reporter molecule, which work together to produce a heterologous gene product in a cell-type, specific manner. The present invention also relates to methods for producing, detecting, imaging, and monitoring the heterologous gene product in a cell or in a subject.
Claims26
An expression vector comprising an effector nucleotide sequence, comprising
- a. a modified tissue specific enhancer sequence;
- b. a tissue specific promoter sequence;
- and
- c. nucleotide sequence encoding a chimeric transactivator operably linked to the modified tissue specific promoter sequence, wherein the encoded transactivator comprises a DNA binding domain and at least one viral transcription activation domain.
1 more element
Dependencies are inferred from the claim text.