Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
AssigneeJapan Tobacco Inc.
InventorsTakuya Tamatani, Katsunari Tezuka, Shinji Sakamoto, Masaharu Takigawa
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Abstract
A human monoclonal antibody useful for the treatment of various diseases caused by human connective tissue growth factor (CTGF) and preventing the onset of the above diseases; medicinal uses thereof; and various monoclonal antibodies having various characteristics against various mammalian CTGFs useful for detecting and assaying CTGFs present in body fluids of mammals suffering from various diseases.
Claims8
1-82. (canceled)
A human monoclonal antibody or a portion thereof, reactive to human CTGF.
A transgenic mouse in which DNA encoding human CTGF is integrated into an endogenous gene locus.
A rat CTGF comprising an amino acid sequence of, or substantially equivalent to an amino acid sequence of SEQ ID NO:2.
A DNA encoding a rat CTGF, wherein the DNA is selected from (a) DNA encoding the amino acid sequence of SEQ ID NO:2 and (b) DNA comprising the nucleotide sequence spanning base pairs 213 to 1256 of SEQ ID NO:1.
Dependencies are inferred from the claim text.