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US 2006/0223130 A1Published application
Detection of post-translationally modified analytes
OwnerDan-Hui Yang, Magdalena Bynuminventors
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Abstract
The invention provides methods of analyzing a sample. In general, the methods involve: a) contacting a sample with an array of capture agents; and b) reading the array to detect the presence of a post-translational modification indicator and an analyte-detection moiety. The analytes of the sample may be contacted with the post-translational modification indicator and analyte-detection moiety at any point in the subject methods. Also provided is a system and kit for performing the subject methods.
Claims24
A method of sample analysis, the method comprising:
- (a) contacting a sample with an array of capture agents;
- (b) contacting said array with a post-translational modification-specific fluorescent dye and an analyte-specific analyte detection moiety;
- and
- (c) reading said array to independently detect:
- i) a said post-translational modification-specific fluorescent dye;
- and
- ii) said analyte-specific analyte detection moiety.
4 more elements
2-3. (canceled)
6-8. (canceled)
A system for sample analysis, comprising:
- a post-translational modification indicator;
- an analyte detection moiety;
- and
- an array of capture agents.
1 more element
A kit comprising:
- a post-translational modification indicator;
- and
- an analyte detection moiety.
Dependencies are inferred from the claim text.