Rhesus monkey Nur77
AssigneeMerck & Co., Inc.
InventorsCarlo Gambone, Azriel Schmidt
Life of this patent
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Abstract
The Macaca mulatta (rhesus monkey) Nur77 (rhNur77) nuclear receptor and the nucleic acid encoding the rhNur77 nuclear receptor are described. Further described are methods for identifying analytes that modulate expression or activity of the rhNur77 nuclear receptor. Analytes that affect Nur77 expression or activity may be used to treat or inhibit inflammatory diseases, for example, osteoarthritis and various bone, neurological, and prostrate disorders. The rhNur77 may also be used to treat various cancers, for example, prostate, ovarian, colon, lung, and gastric cancer.
Claims6
An isolated nucleic acid molecule comprising a nucleotide sequence encoding a rhesus monkey Nur77 polypeptide or fragment thereof having an amino acid sequence of SEQ ID NO:2.
2-17. (canceled)
A vector comprising a nucleic acid encoding a rhesus monkey Nur77 polypeptide or fragment thereof having an amino acid sequence of SEQ ID NO:2 wherein the nucleic acid is operably linked to a heterologous promoter.
Dependencies are inferred from the claim text.