Novel receptor
OwnerAshley Barnes, Alan Wise +4inventors
InventorsAshley Barnes, Alan Wise, Fiona Marshall, Neil Fraser, Julia White, Steven Foord
Life of this patent
Estimating the term…
Abstract
The present invention relates to the novel GABAB receptor subtypes GABAB-R1c and GABAB-R2 as well as to a novel, functional GABAB receptor which comprises a heterodimer of GABAB-R1 and GABAB-R2 receptor subunits. The present invention also relates to variants of the receptors, nucleotide sequences encoding the receptors and variants thereof and novel vectors, stable cell lines, antibodies, screening methods, methods of treatment and methods of receptor production.
Claims3
1-37. (canceled)
A method for identification of a compound which exhibits GABAb receptor modulating activity, comprising contacting the GABAb receptor with a test compound and detecting modulating activity or inactivity, wherein said GABAb receptor comprises a heterodimer between a GABAb-R1 receptor protein and a GABAb-R2 receptor protein wherein the GABAb-R1 comprises the no acid sequence for GABAb-R1a, GABAb-R1b or GABAb-R1c as set forth in FIG. 2 and wherein the GABAb-R2 receptor comprises the amino acid sequence set forth in FIG. 1b.
39-46. (canceled)
Dependencies are inferred from the claim text.