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US 2006/0223109 A1Published application
G protein-coupled receptors
AssigneeAmgen Inc.
InventorsHui Tian, Jiagang Zhao, Jin-Long Chen, Gene Cutler
Life of this patent
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Abstract
The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.
Claims18
An isolated nucleic acid encoding a polypeptide that:
- (i) comprises 80% or greater amino acid sequence identity to the amino acid sequence of SEQ ID NO:2, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, or SEQ NO:14;
- or
- (ii) comprises at least 100 contiguous amino acids of an amino acid sequence of SEQ ID NO:2, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, or SEQ ID NO:14;
- or
- (iii) comprises at least 90% identity to the amino acid sequence of SEQ ID NO:20, SEQ ID NO:22, or SEQ ID NO:24.
2 more elements
An isolated polypeptide comprising:
- (i) 80% or greater amino acid sequence identity to the amino acid sequence of SEQ ID NO:2, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, or SEQ ID NO:14;
- or
- (ii) at least 100 contiguous amino acids of the amino acid sequence of SEQ ID NO:2, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, or SEQ ID NO:14;
- or
- (iii) at least 90% identity to an amino acid sequence of SEQ ID NO:20, SEQ ID NO:22, or SEQ ID NO:24.
2 more elements
A method of detecting cancer cells in a biological sample from a mammal, the method comprising steps of:
- (i) providing the biological sample from the mammal;
- and
- (ii) detecting a nucleic acid molecule encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:14 in a sample from the mammal, wherein an increase in level of the nucleic acid molecule in the sample compared to normal indicates the presence of cancer cells.
Dependencies are inferred from the claim text.