Methods and kits for diagnosing and monitoring hematopoietic cancers
AssigneesHadasit Medical Research Services and Development Ltd., Insight Strategy & Marketing Ltd.
InventorsIris Pecker, Israel Vlodavsky, Ben Katz, Amiram Eldor, Menachem Bitan, Aaron Polliack, Arnon Nagler, Zofia Eldor
Life of this patent
Estimating the term…
Abstract
Methods and kits for distinguishing between heparanase expressing and heparanase non-expressing hematopoietic cells, particularly useful in distinguishing between different types of differentiated and/or undifferentiated lymphomas and leukemias. The methods and kits are designed to detect heparanase expression, or absence thereof, at the gene, protein and/or protein activity levels.
Claims16
1-98. (canceled)
A method of distinguishing between heparanase expressing hematopoietic cells and heparanase non-expressing hematopoietic cells in subject in need thereof, the method comprising monitoring heparanase expression in hematopoietic cells obtained from the subject and, based on a presence or an absence of said heparanase expression, distinguishing between said heparanase expressing hematopoietic cells and said heparanase non-expressing hematopoietic cells, wherein monitoring said heparanase expression is by monitoring heparanase RNA levels using an assay selected from the group consisting of RT-PCR, chip hybridization, RNase protection, in-situ hybridization, primer extension, Northern blot and dot blot analysis.
Dependencies are inferred from the claim text.