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US 2006/0223105 A1Published application
Mass spectrometric methods for detecting mutations in a target nucleic acid
AssigneeSequenom, Inc.
InventorHubert Koster
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Abstract
Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided.
Claims16
A process for detecting one or more target nucleotide sequences in a biological sample, comprising:
- a) amplifying a target nucleic acid molecule, wherein the amplification product is a natural deoxyribonucleic acid;
- b) ionizing and volatilizing the product of step (a);
- and
- c) analyzing the product of step (b) by mass spectrometry, wherein detection of the target nucleotide sequence by mass spectrometry indicates the presence of the target nucleotide sequence in the biological sample.
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Dependencies are inferred from the claim text.