Methods for detecting endocrine cancer
AssigneeMount Sinai Hospital
InventorsGeorge Yousef, Eleftherios Diamandis
Life of this patent
Estimating the term…
Abstract
Kallikrein 12, kallikrein 14, and kallikrein 15 proteins, and nucleic acids encoding the proteins have particular application in the detection of endocrine cancer, in particular ovarian cancer. Kallikrein 12, kallikrein 14, and kallikrein 15 proteins and nucleic acid molecules encoding the proteins constitute new biomarkers for diagnosis and monitoring (i.e. monitoring progression or therapeutic treatment) of endocrine cancer.
Claims36
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A method of assessing whether a subject is afflicted with or has a pre-disposition for endocrine cancer, the method comprising comparing:
- (a) levels of kallikrein 12, kallikrein 14 and/or kallikrein 15 or nucleic acids encoding kallikrein 12, kallikrein 14 and/or kallikrein 15 in a sample from the patient;
- and
- (b) levels of kallikrein 12, kallikrein 14 and/or kallikrein 15 or nucleic acids encoding kallikrein 12, kallikrein 14 and/or kallikrein 15 in samples of the same type obtained from control subjects, wherein significantly altered levels of kallikrein 12, kallikrein 14 and/or kallikrein 15 or nucleic acids encoding kallikrein 12, kallikrein 14 and/or kallikrein 15 relative to the corresponding levels from control subjects of kallikrein 12, kallikrein 14 and/or kallikrein or nucleic acids encoding kallikrein 12, kallikrein 14 and/or kallikrein 15 is an indication that the patient is afflicted with endocrine cancer.
A method for monitoring the progression of endocrine cancer in a subject the method comprising:
- (a) detecting kallikrein 12, kallikrein 14, and/or kallikrein 15 proteins or nucleic acids encoding the proteins in a sample from the patient at a first time point;
- (b) repeating step (a) at a subsequent point in time;
- and
- (c) comparing the levels detected in (a) and (b), and therefrom monitoring the progression of the endocrine cancer.
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Dependencies are inferred from the claim text.