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US 2006/0223058 A1Published application
In vitro association studies
AssigneePerlegen Sciences, Inc.
InventorsDavid Cox, Brad Margus
Life of this patent
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Abstract
Cell and tissue autonomous phenotypes are correlated with genotype information. Correlated genotype information is used to screen individual traits. Methods and systems for correlating cell and tissue autonomous phenotypes to genotype information are provided.
Claims48
A method of correlating a cell or tissue autonomous phenotype to a genotype, the method comprising:
- detecting variance in a cell or tissue autonomous phenotype in a population of cells or tissues;
- accessing genotype information for the cells or tissues in the population;
- and,
- correlating the variance to the genotype information, thereby correlating the cell or tissue autonomous phenotype and the genotype.
1 more element
A method diagnosing, detecting, detecting a predisposition for, predicting an outcome of and/or selecting a treatment regimen for a disease, the method comprising:
- detecting at least one in vitro cell or tissue autonomous phenotype of a cell or tissue from a patient and/or detecting a genotype correlated to the cell autonomous phenotype;
- and,
- accessing a database comprising a correlation between the cell or tissue autonomous phenotype and/or genotype and one or more of:
- a side effect, a side effect predisposition, a disease, a predisposition to a disease, a prognosis of a disease, and/or treatment response or efficacy for a disease;
- and,
- based on the correlation:
- diagnosing, detecting, detecting a predisposition for, predicting an outcome of and/or selecting a treatment regimen for the disease.
4 more elements
Dependencies are inferred from the claim text.