System and method to simulate hemodynamics
AssigneeVictor KRSTEC
InventorsMichael Dancu, John Tarbell
Life of this patent
Estimating the term…
Abstract
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
Claims20
A system configured to produce biomechanical conditions, comprising:
- a specimen chamber;
- a first pump system operatively coupled to provide a fluid flow through the specimen chamber;
- an external pump coupled to the specimen chamber and configured to dynamically provide external pressure to the fluid flow in the specimen chamber;
- and
- a reservoir operatively coupled the specimen chamber.
A method for producing biomechanical conditions, comprising:
- providing a specimen chamber;
- providing at least one upstream pump coupled to an upstream end of the specimen chamber;
- dynamically providing external pressure in the specimen chamber using an external pump;
- and
- operatively coupling a reservoir to at least one of the specimen chamber, the upstream pump and the external pump.
Dependencies are inferred from the claim text.