System and method to simulate hemodynamics
AssigneeVictor KRSTEC
InventorsMichael Dancu, John Tarbell
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Abstract
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
Claims20
A system configured to produce biomechanical conditions, comprising:
- a specimen chamber;
- a first pump system operatively coupled to the specimen chamber;
- a steady flow pump operatively coupled to the specimen chamber and the first pump system;
- and
- a reservoir operatively coupled to the specimen chamber, wherein the first pump system and the steady flow pump are configured to generate pressure and flow conditions in the specimen chamber.
A method for producing biomechanical conditions, comprising:
- providing a specimen chamber;
- providing at least one pump operatively coupled to the specimen chamber;
- providing a steady flow pump operatively coupled to the specimen chamber and said at least one pump;
- and
- operatively coupling a reservoir to at least one of the specimen chamber, the steady flow pump and said at least one pump.
Dependencies are inferred from the claim text.