Composition of and method for preparing stable particles in a frozen aqueous matrix
OwnerJames Kipp, Mark Doty +3inventors
InventorsJames Kipp, Mark Doty, Christine Rebbeck, Sean Brynjelsen, Jamie Konkel
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Abstract
The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.
Claims104
A composition comprising a suspension of particles of a poorly water soluble compound in a frozen aqueous matrix, the compound selected from the group consisting of a cosmetic agent, a diagnostic agent and a photographic agent.
(canceled)
(canceled)
A method for stabilizing a suspension of a poorly water soluble compound in an aqueous matrix, the compound being selected from the group consisting of a cosmetic agent, a diagnostic agent and a photographic agent, the method comprising the steps of:
- providing the suspension in an aqueous matrix;
- and freezing the aqueous suspension.
(canceled)
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A method for administering a suspension of a poorly water soluble pharmaceutical agent or cosmetic in a frozen aqueous matrix to a patient comprising the steps of:
- providing the frozen suspension of the pharmaceutical agent or cosmetic;
- thawing the frozen suspension;
- and administering the thawed suspension to the patient by a route selected from the group consisting of:
- parenteral injection (intravenous, intra-arterial, intrathecal, intraperitoneal, intraocular, intra-articular, intradural, intramuscular, intradermal or subcutaneous injection), oral, pulmonary, ophthalmic, or topical.
Dependencies are inferred from the claim text.