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AssigneeLTS Lohmann Theraple-Systeme AG
InventorsMarkus Krumme, Albert Radlmaier, Sascha General, Michael Dittgen, Keith Jensen
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The invention relates to a pharmaceutical composition in the form of a system in film form for transmucosal administration of steroid hormones. An administration system for steroid hormones which dissolves in the mouth and which releases with a high bioavailability is disclosed. The administration system in film form dissolves in the mouth preferably in a period of less than 30 min, and the steroid hormone entering the bloodstream transmucosally from the administration system leads to a rapid rise in the concentration in the blood. It is thus possible to achieve a maximum concentration of this steroid hormone in the blood in a period of less than 60 min after administration.
An administration system in film form for transmucosal administration of a steroid hormone, comprising 0.01-50% by weight of a steroid hormone and 50-99.99% by weight of a carrier material.
The use of a steroid hormone for producing a medicament for the treatment of disorders and/or dysfunctions attributable to a steroid hormone deficiency.
A process for producing an administration system in film form for transmucosal administration of a steroid hormone, characterized in that the steroid hormone is mixed in the form of a solution in a pharmaceutically acceptable solvent with a water-containing mixture of a carrier material, the mixture produced thereby is spread out as a thin layer and is dried by removing the solvent and with formation of a film.
A method for the treatment of disorders and/or dysfunctions attributable to a steroid hormone deficiency, characterized in that in a first step an administration system in film form which comprises at least one steroid hormone is applied to the mucosa in the mouth, and in a second step the at least one steroid hormone penetrates transmucosally into the bloodstream.
Dependencies are inferred from the claim text.