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US 2006/0222706 A1Published application
Formulations of Fenofibrate
OwnerMoshe Flashner-Barak, E. Lernerinventors
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OwnerMoshe Flashner-Barak, E. Lernerinventors
Estimating the term…
The invention provides at least a composition for the treatment of elevated levels of triglycerides, comprising a therapeutically effective amount of fenofibrate or another fibrate drug intimately associated with menthol or a surfactant mixture, wherein the menthol can be menthol or menthol surfactant mixture, and wherein the surfactant mixture can be a mixture of a polyethylene glycol and a poloxamer such as PGE 1000 and poloxamer 407. The invention also provides a method for the treatment of elevated levels of triglycerides in a subject, comprising administering to the subject a composition comprising a therapeutically effective amount of fenofibrate or another fibrate drug and menthol or a surfactant mixture, wherein the fenofibrate or the other fibrate drug is in intimate association with the menthol or surfactant mixture, wherein the menthol can be menthol or menthol surfactant mixture, and wherein the surfactant mixture can be a mixture of a polyethylene glycol and a poloxamer such as PGE 1000 and poloxamer 407.
A composition comprising fenofibrate or another fibrate drug, and at least one pharmaceutical excipient, wherein the composition has a dissolution of (a) at least about 80% in about 15 minutes, as measured using a rotating blade method at 150 rpm, in 50 ml of dissolution medium composed of 0.1N HCl at 37° C.;
A composition comprising fenofibrate or another fibrate drug, which when administered to a dog weighing about 10 kg (a) at a dose of about 10 mg presents an average AUC0-t of fenofibric acid about 4923 (ng*hr/ml);
A composition comprising fenofibrate, menthol and at least one surface active agent.
A method of preparing a fenofibrate composition, comprising mixing at least one surface active agent and fenofibrate in melted menthol until at least some of the fenofibrate dissolves.
A composition comprising fenofibrate or another fibrate drug in intimate association with a polyethylene glycol and a poloxamer.
A composition for the treatment of elevated levels of triglycerides that comprises at least one surface active agent, menthol and a therapeutically effective amount of fenofibrate or another fibrate drug, wherein the fenofibrate or the other fibrate drug is dissolved in menthol, and when the composition is tested in 500 ml 0.5% Sodium lauryl sulfate in water at 37° C. and 50 rpm at least 70% of the fenofibrate or the other fibrate drug in the composition are dissolved in 5 minutes.
A composition comprising fenofibrate or another fibrate drug in intimate association with a surfactant mixture.
Dependencies are inferred from the claim text.