Compositions with hydrophilic drugs in a hydrophobic medium
AssigneeMcNeil-PPC, Inc.
InventorsNeema Kulkarni, Kanji Meghpara
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Abstract
In various embodiments of the present invention, a capsule is provided including a hydrophobic inner layer and at least one hydrophilic outer layer. The hydrophobic layer may include a hydrophilic component such as an active pharmaceutical ingredient (API) which may be fully encapsulated, partially encapsulated or part of an adsorption complex. Such capsules experience no or minimal cracking or breaking in the outer layer.
Claims20
A capsule comprising a hydrophobic inner layer and at least one hydrophilic outer layer, said hydrophobic inner layer comprises a hydrophilic active pharmaceutical ingredient in a therapeutically effective amount;
- said active pharmaceutical ingredient is fully encapsulated, partially encapsulated or part of an adsorption complex.
The seamless capsule of claim 17, wherein said phenylephrine is encapsulated, partially encapsulated or adsorbed with a material selected from the group consisting of cellulose, sulphonated polymers, acrylic co-polymers, trisilicates, polystyrenes, cyclodextrins and combinations thereof.
A package comprising a dispenser and a seamless capsule;
- said seamless capsule comprising a hydrophobic inner layer and at least one hydrophilic outer layer, said hydrophobic inner layer comprises a hydrophilic active pharmaceutical ingredient in a therapeutically effective amount, said active pharmaceutical ingredient is partially encapsulated, fully encapsulated or is part of an adsorption complex;
- and said package has drug facts attached thereto.
A capsule comprising a hydrophobic inner layer and at least one hydrophilic outer layer, said hydrophobic inner layer comprises a hydrophilic component;
- said hydrophilic component experiences none or minimal migration to said outer hydrophilic outer layer.
Dependencies are inferred from the claim text.