Stabilized topotecan liposomal composition and methods
OwnerChoon Oh, Francis Ignatiousinventors
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Abstract
A topotecan liposomal composition which can be reconstituted from a lyophilized form to an injectable liposome suspension having selected liposome sizes in the size range between 0.05 and 0.25 microns, and between about 85-100% liposome-entrapped topotecan is disclosed.
Claims8
A lyophilized topotecan liposomal composition comprising topotecan, liposomes and cryprotectant, wherein topotecanis substantially entrapped in the liposome interior.
A lyophilized topotecan liposomal composition comprising topotecan, liposomes and cryprotectant, that can be reconstituted with water to form a reconstituted composition wherein at least about 85% of the topotecan in the composition is liposome-entrapped topotecan, and wherein about 85% of the liposomes in said composition have sizes of about 0.05 to about 0.25 microns.
A reconstituted lyophilized topotecan liposomal composition comprising topotecan, liposomes and cryprotectant, wherein:
- about 85% of the liposomes in said composition have sizes of about 0.05 to about 0.25 microns,
- at least about 85% of the topotecan in the composition is liposome-entrapped topotecan;
- and
- the topotecan/lipid ratio is between about 0.02 to about 0.4 by weight, wherein the lipid contituents comprise cholesterol and a vesicle-forming lipid that form the liposome.
Dependencies are inferred from the claim text.