Dermatological compositions and salts for the treatment of dermatological diseases

A dermatological composition comprising:

• Oxaprozin or a closely related compound provided in a form of a water-soluble salt, wherein the closely related compound is defined by the general formula I:
• and
• ii) a vehicle comprising one or more dermatologically acceptable ingredient(s) or carrier(s), wherein
• R is selected from C1-3-alkyl, C2-3-alkenyl, and C2-3-alkynyl and R is optionally derivatized by substitution of one hydrogen atom with CN, halogen OH, NH2 and NO2;
• R1 and R2 independently designate radicals selected from hydrido, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxyl, CO, CHO, CO-Me, CO-Et, CN, halogen, OH, OR′, NH2, NHR′, NR′R″, NO2, HSO2 and R7—SO2;
• R3 and R4 independently designate radicals selected from hydrido, C1-6-alkyl and C2-6-alkenyl;
• R5 designate radicals selected from OH, OR6, NH2, NHR′, NR′R″, SH and SR6;
• R6 designate radicals selected from C1-6-alkyl, C2-6-alkenyl and aryl;
• R7 designate radicals selected from C1-6-alkyl, aryl, NH2, NHR′ and NR′R″;
• R′ and R″ designate the same or different group selected from C1-6-alkyl and C2-6-alkenyl;
• and
• “aryl” means phenyl or mono-substituted phenyl wherein one hydrogen have been replaced by substituents selected from C1-6-alkyl, C2-6-alkenyl, C1-6-alkoxyl, CO, CHO, CN, halogen, OH, NH2 and NO2;
• and wherein the oxygen of the oxazole ring optionally is replaced with sulfur (S) to provide a thiazole ring.