Stannsoporfin compositions, drug products and methods of manufacture
AssigneeWellSpring Pharmaceutical Corporation
InventorsGeorge Drummond, Philip Lang
Life of this patent
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Abstract
Pharmaceutical compositions including stannsoporfin, drug products incorporating pharmaceutical compositions, methods of making pharmaceutical compositions, and methods of treating hyperbilirubinemia with drug products and compositions are disclosed.
Claims20
1-32. (canceled)
A pharmaceutical composition comprising stannsoporfin in an aqueous solution at a concentration of at least about 20 mg/ml and having a physiological osmolarity.
A pharmaceutical composition comprising stannsoporfin in an aqueous solution at a concentration of at least about 20 mg/ml and having a shelf life at room temperature of at least about 3 months.
A method of making a pharmaceutical composition comprising:
- mixing a pre-determined amount of stannsoporfin with a buffering agent in aqueous solution;
- increasing the pH of the solution to a pH of at least about 10 to facilitate dissolution of the stannsoporfin in the solution;
- and
- decreasing the pH of the solution to a pH of less than or equal to about 8.
Dependencies are inferred from the claim text.