Molecular antigen array
AssigneeCytos Biotechnology AG
InventorsPeter Sebbel, Nicolas Dunant, Martin Bachmann, Alain Tissot, Franziska Lechner, Wolfgang Renner, Frank Hennecke, Lars Nieba
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Abstract
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a core particle that is coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions.
Claims21
1-85. (canceled)
A composition comprising a bacterial pilus to which an antigen or antigenic determinant has been attached by a covalent bond.
A composition comprising:
- (a) a non-natural molecular scaffold comprising:
- (i) a core particle selected from the group consisting of:
- (1) a bacterial pilus or pilin protein;
- and
- (2) a recombinant form of a bacterial pilus or pilin protein;
- and
- (ii) an organizer comprising at least one first attachment site,
- wherein said organizer is connected to said core particle by at least one covalent bond;
- and
- (b) an antigen or antigenic determinant with at least one second attachment site, said second attachment site being selected from the group consisting of:
- (i) an attachment site not naturally occurring with said antigen or antigenic determinant;
- and
- (ii) an attachment site naturally occurring with said antigen or antigenic determinant,
- wherein said second attachment site is capable of association through at least one non-peptide bond to said first attachment site;
- and
- wherein said antigen or antigenic determinant and said scaffold interact through said association to form an ordered and repetitive antigen array.
A composition comprising:
- (a) a non-natural molecular scaffold comprising:
- (i) a Hepatitis B virus capsid protein, modified such that the cysteine residues corresponding to positions 48 and 107 in SEQ ID NO:134 are either deleted or substituted with another amino acid;
- and
- (ii) an organizer comprising at least one first attachment site,
- wherein said organizer is connected to said core particle by at least one covalent bond;
- and
- (b) an antigen or antigenic determinant with at least one second attachment site, said second attachment site being selected from the group consisting of:
- (i) an attachment site not naturally occurring with said antigen or antigenic determinant;
- and
- (ii) an attachment site naturally occurring with said antigen or antigenic determinant,
- wherein said second attachment site is capable of association through at least one non-peptide bond to said first attachment site;
- and
- wherein said antigen or antigenic determinant and said scaffold interact through said association to form an ordered and repetitive antigen array.
Dependencies are inferred from the claim text.