Methods and compositions for modulating the activity of PDE5
OwnerJoseph Beavo, Jackie Corbin +8inventors
InventorsJoseph Beavo, Jackie Corbin, Kenneth Ferguson, Sharron Francis, Ann Kadlecek, Linda McAllister-Lucas, Kate Loughney, William Sonnenburg, Melissa Thomas, Sergei Rybalkin
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Abstract
The present invention provides agents such as agonists, antibodies, antagonists or inhibitors to modulate the activity of PDE5 proteins. These compositions and methods are useful for the diagnosis or treatment of conditions associated with the presence, the deficiency, altered levels, or altered activity of PDE5 proteins.
Claims30
A method for modulating the enzymatic activity of PDE5, comprising contacting PDE5 with an effective amount of an agent that binds PDE5 and activates or inhibits PDE5.
A method for identifying an agent that specifically binds to PDE5 comprising:
- a) contacting PDE5 with an effective amount of a test agent;
- and
- b) determining if the test agent specifically binds PDE5.
A method for identifying an agent that specifically binds to PDE5 so as to modulate the enzymatic activity of PDE5 comprising:
- a) contacting PDE5 with an effective amount of a test agent;
- b) determining if the test agent specifically binds PDE5;
- and
- c) testing for activation or inhibition of PDE5 activity.
A method of using an agent that modulates the enzymatic activity of PDE5 in a pharmaceutical composition for treating a subject for a condition where inhibition of PDE5 is of therapeutic benefit, comprising administering to said subject a therapeutically effective amount of the pharmaceutical composition so as to inhibit PDE5.
A method of using an agent that modulates the enzymatic activity of PDE5 in a pharmaceutical composition for treating a subject for a condition where activation of PDE5 is of therapeutic benefit, comprising administering to said subject a therapeutically effective amount of the pharmaceutical composition so as to activate PDE5.
Dependencies are inferred from the claim text.