Proliferation of muc1 expressing cells
AssigneeMinerva Biotechnologies Corporation
InventorCynthia Bamdad
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Abstract
The present application discloses a method for stimulating or enhancing proliferation of a population of cells by activating MUC1 receptor on the cells.
Claims27
A method for stimulating or enhancing proliferation of a population of cells by activating MUC1 receptor on the cells.
A method for treating a patient displaying symptoms of a low white blood count comprising administering to the patient an agent for activating MUC1 receptor in cells.
A method for treating a patient, who displays symptoms indicating that a medicinal benefit would be achieved by causing immature cells to proliferate, with an agent that activates MUC1 receptor in cells.
A method for treating a patient, who displays symptoms that could be relieved by causing immature cells to proliferate by administering a DNA encoding (i) MUC1, (ii) a fragment of MUC1 that is displayed on the cell surface, or (iii) the MGFR portion of MUC1, to the patient at the site for which the cells are desired be proliferated.
A method for stimulating proliferation of immature cells in vitro by introducing DNA encoding MUC1, a fragment of MUC1 that is displayed on the cell surface, or the MGFR portion of MUC1.
A composition comprising:
- (i) an agent that multimerizes the MGFR portion of MUC1;
- (ii) an agent that increases the cleavage of MUC1 to the growth factor receptor form;
- or (iii) a ligand that activates the MGFR portion of the MUC1 receptor;
- and a pharmaceutically-acceptable carrier.
Dependencies are inferred from the claim text.