Prevention, decrease, and/or treatment of immunoreactivity by depleting and/or inactivating antigen presenting cells in the host
AssigneeYale University
InventorsWarren Shlomchik, Mark Shlomchik
Life of this patent
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Abstract
The invention includes compositions and methods for depleting and/or inactivating antigen presenting cells, or for otherwise impairing the biological function of antigen presenting cells, which compositions are useful for treatment of graft versus host disease and other immune diseases.
Claims34
A method of treating graft versus host disease (GVHD) in a host mammal, said method comprising:
- (a) transferring hematopoietic cells from a donor mammal to said host mammal;
- and
- (b) depleting and/or inactivating antigen presenting cells in a population of hematopoietic cells in said host mammal with an antigen presenting cell depleting and/or inactivating composition, wherein said graft versus host disease is treated in said host mammal by virtue of said depletion and/or inactivation of said antigen presenting cells.
The method of 1, wherein said antigen depleting and/or inactivating composition is delivered to said antigen presenting cell in a vector selected from the group consisting of a viral vector and a non-viral vector.
A method of preventing and/or decreasing graft versus host disease (GVHD) in a host mammal, said method comprising:
- (a) transferring hematopoietic cells from a donor mammal to said host mammal;
- and
- (b) depleting and/or inactivating antigen presenting cells in a population of hematopoietic cells in said host mammal with an antigen presenting cell depleting and/or inactivating composition, wherein said graft versus host disease is prevented and/or decreased in said host mammal by virtue of said depletion and/or inactivation of antigen presenting cells.
The method of 23, wherein said antigen depleting and/or inactivating composition is delivered to said antigen presenting cell in a vector selected from the group consisting of a viral vector and a non-viral vector.
Dependencies are inferred from the claim text.