Methods for therapeutic use of brain derived neurotrophic factor in the entorhinal cortex
AssigneeThe Regents of the University of California
InventorMark Tuszynski
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Abstract
A protocol for use of growth factors to stimulate neuronal cell growth and activity in trkB receptor containing cortical tissues, including the entorhinal and hippocampal cortices. The method introduces exogenous growth factor, such as BDNF, NT-4/5 and NT-3, into the EC. The method is useful in therapy of defective, diseased and damaged neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative conditions such as Alzheimer's disease or for normal aging.
Claims19
A method to stimulate or support cortical neurons in a subject's brain, the method comprising delivering a nervous system growth factor composition consisting of brain-derived neurotrophic factor (BDNF) or NT-4/5 to neurons in cortical tissues containing trkB receptors.
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