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US 2006/0222627 A1Published application
Optimizing pharmacodynamics of therapeutic agents for treating vascular tissue
OwnerAndrew Carterinventor
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Abstract
An implant such as a stent is coated with a biodegradable or non-biodegradable polymer having therein an antiproliferative/immunosuppressive agent and a compound which reduces the rate of metabolism of the antiproliferative/immunosuppressive agent thereby inhibiting restenosis.
Claims43
A composition comprising:
- a CYP modulator;
- and
- an antiproliferative/immunosuppressive agent;
- wherein the weight ratio of the CYP modulator to the antiproliferative/immunosuppressive agent is in a range of from about 1:100000 to about 100000:1.
1 more element
A method of modulating CYP function in order to alter biotransformation of compounds in a vessel wall of a subject, the method comprising:
- administering at a target site on a vessel wall an effective amount of an antiproliferative/immunosuppressive agent;
- and
- administering to the subject an effective amount of a CYP modulator, wherein the weight ratio of the CYP inducer to the antiproliferative/immunosuppressive agent is about 1:100000 to about 100000:1;
- and
- altering the arterial tissue concentration of the antiproliferative/immunosuppressive agent at the target site.
2 more elements
Dependencies are inferred from the claim text.