Nanoparticles for therapeutic and diagnostic applications
OwnerPriyabrata Mukherjee, Resham Bhattacharya +1inventors
InventorsPriyabrata Mukherjee, Resham Bhattacharya, Debabrata Mukhopadhyay
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Abstract
This document provides materials and methods related to nanoparticles. For example, nanoparticle compositions, methods for making nanoparticle compositions, and methods for using nanoparticle compositions are provided. In some cases, the nanoparticles are gold (e.g., colloidal gold) nanoparticles. A nanoparticle can include one or more agents linked to its surface, such as therapeutic and/or diagnostic agents, and can be from about 1 nm to about 10 nm in size.
Claims32
A composition consisting of gold nanoparticles, wherein each of said gold nanoparticles is from about 4 nm to about 6 nm in size and comprises, linked to its surface, (a) at least one anti-VEGF antibody, (b) at least one molecule of gemcitabine, (c) at least one molecule of Gd(III)-DOTA, and wherein at least about 99 percent of the gold nanoparticles of said composition lack PEG or a PEG-derivative linked to their surfaces.
A composition comprising metal nanoparticles, wherein each of the metal nanoparticles is from about 1 nm to about 10 nm in size, and wherein each metal nanoparticle includes at least one agent linked to its surface, and wherein at least about 30 percent of the metal nanoparticles of the composition lack PEG or a PEG-derivative linked to the surface of the nanoparticle.
A method for treating or ameliorating one or more symptoms of cancer in a patient, the method comprising administering to the patient a pharmaceutically acceptable composition comprising a gold nanoparticle having an anti-angiogenesis agent linked to its surface.
A method for inhibiting angiogenesis from a tumor in a patient, the method comprising administering to the patient a pharmaceutically acceptable composition comprising a gold nanoparticle comprising an anti-angiogenesis agent linked to its surface.
A method for imaging a tumor in a patient, the method comprising:
- a) administering to the patient a pharmaceutically acceptable composition comprising a gold nanoparticle having an anti-VEGF antibody linked to its surface and a diagnostic agent linked to its surface;
- and
- b) imaging the patient.
A method for reducing cell proliferation in a tumor in a patient, the method comprising:
- a) administering to the patient a pharmaceutically acceptable composition comprising a gold nanoparticle having a chemotherapeutic agent linked to its surface.
A method for reducing cell proliferation in a tumor in a patient, the method comprising:
- a) administering to the patient a pharmaceutically acceptable composition comprising a gold nanoparticle having an anti-angiogenesis agent linked to its surface.
A method for inducing apoptosis in a cell, the method comprising:
- a) contacting the cell with a composition comprising a gold nanoparticle having an anti-angiogenesis agent linked to its surface.
A method for monitoring whether or not a cancer therapy has had an effect on a tumor in a patient, the method comprising:
- a) administering to the patient a cancer therapy comprising a pharmaceutically acceptable composition comprising a gold nanoparticle having a chemotherapeutic agent linked to its surface and a diagnostic agent linked to its surface;
- b) obtaining a first image of the tumor in the patient after the administration;
- c) obtaining a second image of the tumor in the patient after a pre-determined time period;
- and
- d) comparing the first and second images in order to determine whether or not the cancer therapy has affected the tumor.
Dependencies are inferred from the claim text.