Back to results
US 2006/0222591 A1Published application
Method for monitoring early treatment response
AssigneeReceptomon, LLC
InventorJoseph Norfray
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeReceptomon, LLC
InventorJoseph Norfray
Estimating the term…
Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline present in the endomembranes of the cancerous tissue before and after treatment; the treatment comprises administration of a cytotoxic therapy, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. The decrease in the amount of Choline represents the decrease in the internal cell membrane as a result of down regulation of the organelles and their secretory granules and their transport vesicles. Disclosed also is a method for determining effectiveness of a cytotoxic treatment of cancer. In addition, a method for monitoring protein translation related to the cytotoxic treatment of cancer is disclosed.
A method for monitoring early treatment response of a cancer treatment comprising measuring, by Magnetic Resonance Spectroscopy (MRS), the amount of Choline present in the endomembranes of the cancerous tissue before and after cytotoxic treatment, wherein said treatment comprises administration of cytotoxic therapy, whereby a decrease in the amount of Choline after treatment is indicative of a positive response.
A method for monitoring cancer treatment comprising:
A method for determining effectiveness of a molecule as a drug, or radiation, for treating cancer comprising administering an amount of the molecule or radiation to an animal having a cancerous tissue and measuring, by Magnetic Resonance Spectroscopy, the amount of Choline present in the endomembranes of the cancerous tissue before and after administering the molecule or radiation, wherein said molecule or radiation comprises a cytotoxic agent, whereby a decrease in the amount of Choline after administering said molecule or radiation is indicative of its effectiveness.
A method for monitoring protein translation comprising administering an amount of the molecule or radiation to an animal having a cancerous tissue and measuring, by Magnetic Resonance Spectroscopy, the amount of Choline present in the endomembranes of the cancerous tissue before and after administering the molecule or radiation.
Dependencies are inferred from the claim text.