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AssigneeBioArray Solutions, Ltd.
InventorsMichael Seul, Xiongwu Xia, Chiu Chau
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Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
1-73. (canceled)
A method of blinding a multiplexed assay where the party conducting the assay does not know the results, and also of ensuring that assay information and results remain associated with the sample which is assayed, where the assay involves contacting a sample with an array of encoded receptors wherein a ligand in the sample is predicted to associate with a receptor in the array, and wherein the encoding of the array and the assay results can be imaged, comprising:
An integer representation of the configuration of a multi-constituent planar array of L encoded beads wherein there are n distinguishable types of beads, the code having Q1, Q2, Q3, Qp≧n elements, and wherein each bead is assigned a (R+1)-tuple of integers in which one field represents the position index, l, where 1≦l≦L, and each of the remaining fields represents an exponent, x, where 1≦x≦Qp.
A method of encrypting the identity of a type of receptor, among multiple receptor types, which is attached to particular encoded carriers in an array of encoded carriers, comprising:
(canceled)
Dependencies are inferred from the claim text.