Separating agent for chromatography and process for producing the same
OwnerYoshio Okamoto, Chiyo Yamamotoinventors
Life of this patent
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Abstract
A separating agent for chromatography which comprises a polysaccharide derivative having a structure in which part of the hydroxy groups present in the polysaccharide which have been crosslinked to each other through crosslinking molecules and the hydroxy groups present in the polysaccharide which have not been crosslinked have been modified with modifying molecules. The polysaccharide derivative is not in the state of being carried on a carrier, and has been formed into, e.g., beads. The separating agent is less likely to dissolve in elution solvent and enables a large amount of a compound to be optically resolved at a time. It can withstand a high pressure.
Claims14
A separating agent for chromatography using a polysaccharide derivative derived from a polysaccharide, wherein:
- the polysaccharide derivative has a structure in which part of hydroxyl groups present in the polysaccharide are crosslinked one another through a crosslinking molecule and non-crosslinked hydroxyl groups present in the polysaccharide are each modified with a modifying molecule;
- and
- the polysaccharide derivative is not carried on a carrier.
A process for producing a separating agent for chromatography, comprising the steps of:
- introducing protective groups into part of hydroxyl groups present in a polysaccharide;
- modifying with a modifying molecule each of hydroxyl groups remained in the polysaccharide having the protective groups introduced;
- releasing the introduced protective groups to recover the hydroxyl groups;
- and
- crosslinking the recovered hydroxyl groups to one another through a crosslinking molecule.
A process for producing a separating agent for chromatography, comprising the steps of:
- crosslinking part of hydroxyl groups present in the polysaccharide to one another through a crosslinking molecule;
- and
- modifying with a modifying molecule each of hydroxyl groups remained in the polysaccharide crosslinked through the crosslinking molecule.
Dependencies are inferred from the claim text.