Device with engineered surface architecture coating for controlled drug release
AssigneeLabcoat, Ltd.
InventorArthur Rosenthal
Life of this patent
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Abstract
In one embodiment of the present invention a coating topology, or engineered surface architecture that may be referred to as a microdroplet deposited engineered surface architecture is provided. A plurality of drops are placed on the stent with the purpose, of building up individual units of coating material on the outer stent surface. This architecture results in a coating that uses less material, i.e., polymer, solvent, medicine, while at the same time providing for better, and determinable, drug kinetics, approaching 100% delivery and better mechanical operation of the coating binding to the stent.
Claims68
A medical device, comprising:
- an abluminal surface;
- material disposed on the abluminal surface, the material comprising an engineered surface architecture,
- wherein the engineered surface architecture comprises material extending a first height from the abluminal surface and material extending a second height from the abluminal surface.
A method, comprising:
- providing a device having a first surface;
- and
- applying a first plurality of drops of a first material on the first surface,
- wherein the first material comprises, a polymer and a drug having a ratio, by weight, therebetween, to result in a plurality of islands of material disposed on the first surface, and
- wherein each of the islands of material comprises:
- a first portion of material having a first height L1;
- and
- a second portion of material having a second height L2;
- and
- wherein the second height L2 is greater than the first height L1.
A device, comprising:
- a first surface;
- and
- a plurality of discrete islands of material deposited on the first surface,
- wherein each of the islands of material comprises:
- an inner ring of material having an inner height L1 and a first radius R1;
- and
- an outer ring of material having an outer height L2, an inner radius
- substantially equal to the first radius R1 and an outer radius R2;
- wherein the second radius R2 is greater than the first radius R1 and the outer height L2 is greater than the inner height L1.
A method, comprising:
- providing a device having a first surface;
- applying a first plurality of drops of a first material on the first surface,
- wherein the first material comprises, a polymer and a drug having a ratio, by weight, therebetween to result in a plurality of islands of material disposed on the first surface,
- wherein each of the islands of material comprises:
- an inner ring of material having an inner height L1 and a first radius R1;
- an outer ring of material having an outer height L2, an inner radius substantially equal to the first radius R1 and an outer radius R2;
- wherein the outer radius R2 is greater than the first radius R1 and the outer height L2 is greater than the inner height L1.
A device, comprising:
- a first surface;
- and
- a plurality of discrete islands of material deposited on the first surface,
- wherein each of the islands of material comprises:
- a first elliptical portion of material having a first height L1;
- and
- a second elliptical portion of material having a second height L2, the second elliptical portion positioned about the first elliptical portion;
- wherein the second height L2 is greater than the first height L1.
Dependencies are inferred from the claim text.