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US 2006/0217797 A1Published application
Asymmetric drug eluting hemodialysis graft
OwnerSamuel Wonginventor
Life of this patent
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Abstract
A hemodialysis graft has one end provided with a deposit containing an anti-stenotic agent. The coated end is connected to a vein to provide protection against stenosis occurring at the venous anastomosis.
Claims30
A hemodialysis graft, comprising:
- a cylindrical tube having a lumen therethrough, a first open end and an opposed second open end, the tube having an interior surface and an exterior surface;
- a first coating deposit located at the first open end of the tube and extending toward the second open end along the interior surface a first predetermined distance;
- and
- a second coating deposit located at the first open end of the tube and extending toward the second open end along the exterior surface a second predetermined distance;
- wherein the first coating deposit comprises a first therapeutic agent and the second coating deposit comprises a second therapeutic agent.
2 more elements
A graft, comprising:
- a substantially cylindrical and hollow tube of a predetermined longitudinal length having a distal end with a distal opening, a proximal end with a proximal opening, an interior surface and an exterior surface;
- a first coating deposit located substantially only on the interior surface at the distal end and extending proximally and longitudinally a first predetermined distance;
- and
- a second coating deposit located substantially only on the exterior surface at the distal end and extending proximally and longitudinally a second predetermined distance,
- wherein the first coating deposit comprises a first therapeutic agent and the second coating deposit comprises a second therapeutic agent, and
- wherein the tube comprises a substantially impermeable material.
3 more elements
A method of making an asymmetric drug eluting hemodialysis graft, the method comprising:
- providing a substantially cylindrical and hollow tube of a substantially impermeable material, the tube having a predetermined longitudinal length, a distal end with a distal opening, a proximal end with a proximal opening, an interior surface and an exterior surface;
- applying a first coating substantially only on the interior surface at the distal end and extending proximally and longitudinally a first predetermined distance, the first coating comprising a first therapeutic agent;
- applying a second coating substantially only on the exterior surface at the distal end and extending proximally and longitudinally a second predetermined distance, the second coating comprising a first therapeutic agent;
- and
- applying the first and second coating such that substantially none of the first and second coating is applied at the interior and exterior surfaces of the proximal end of the tube.
2 more elements
A method, comprising:
- providing a hemodialysis graft, the hemodialysis graft comprising:
- a distal end, a proximal end, an interior surface and an exterior surface;
- a first coating deposit located substantially only on the interior surface at the distal end and extending proximally and longitudinally a first predetermined distance, the first coating deposit comprising a first therapeutic agent;
- and
- a second coating deposit located substantially only on the exterior surface at the distal end and extending proximally and longitudinally a second predetermined distance, the second coating deposit comprising a second therapeutic agent;
- attaching the distal end of the hemodialysis graft to a vein of a patient;
- and attaching the proximal end of the hemodialysis graft to an artery of the patient,
- wherein at least one of the first and second therapeutic agents elutes from the respective coating deposit.
5 more elements
Dependencies are inferred from the claim text.