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US 2006/0217631 A1Published application
Method for automated analysis of submaximal F-waves
AssigneeNeuroMetrix, Inc.
InventorsXuan Kong, Pansy Bansal, Shai Gozani
Life of this patent
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Abstract
A novel submaximal F-wave acquisition and analysis system that employs computational intelligence to set up submaximal F-wave acquisition conditions and to extract submaximal F-wave features automatically, without operator intervention.
Claims24
A method for acquiring and analyzing F-waves under a submaximal stimulation condition, the method comprising:
- (i) applying a series of stimuli of variable intensity to a nerve;
- (ii) recording a series of early responses;
- (iii) determining a submaximal stimulation level for F-wave acquisition and analysis;
- (iv) applying a series of stimuli of submaximal intensity to a nerve;
- (v) recording a series of late responses;
- (vi) regulating the submaximal stimulation and acquisition condition based on late response features;
- (vii) analyzing late response to regulate the processing condition of F-wave features;
- and
- (viii) characterizing F-wave features with trace-by-trace and/or total waveform set analysis.
6 more elements
A method for diagnosing a disorder in a patient comprising:
- (i) applying a series of stimuli of variable intensity to a nerve;
- (ii) recording a series of early responses;
- (iii) determining a submaximal stimulation level for F-wave acquisition and analysis;
- (iv) applying a series of stimuli of submaximal intensity to a nerve;
- (v) recording a series of late responses;
- (vi) regulating the submaximal stimulation and acquisition condition based on late response features;
- (vii) analyzing late responses to regulate the processing condition of F-wave features;
- (viii) characterizing F-wave features with trace-by-trace and/or total waveform set analysis;
- and
- (ix) comparing F-wave characteristics based on the submaximal late responses with those of normal character and those of known disorder.
7 more elements
A system for analyzing submaximal F-waves comprising:
- (i) a stimulation electrode;
- (ii) a stimulation circuit connected to the stimulation electrode for applying a series of stimuli to a nerve;
- (iii) a detection electrode;
- (iv) a detection circuit connected to the detection electrode;
- and
- (v) an analyzer connected to the detection circuit and stimulation circuit and adapted to conduct submaximal F-wave analysis by:
- (a) recording a series of early responses detected by the detection circuit and evoked by stimuli with variable intensities delivered by the stimulation circuit;
- (b) determination of a submaximal stimulation level based on an early response feature space;
- (c) recording a series of late responses detected by the detection circuit and evoked by submaximal stimulation;
- (d) regulating the stimulation circuit by the analyzer based on late response features;
- (e) recording and analyzing a series of late responses detected by the detection circuit;
- and
- (f) altering the F-wave analysis setup and late response traces;
- and
- (vi) apparatus for characterizing the F-wave features.
12 more elements
A method for submaximal F-wave acquisition and analysis, the method comprising:
- (i) applying a series of stimuli of increasing intensity to a nerve;
- (ii) recording a series of early responses;
- (iii) determining the submaximal stimulation intensity based on a stimulus response curve and a target ratio between the submaximal and supramaximal early response magnitudes;
- (iv) applying a series of stimuli of fixed intensity at the submaximal level to the nerve;
- (v) recording a series of late responses;
- (vi) detecting possible A-wave and H-reflex responses and excluding those segments from the late responses;
- and
- (vii) extracting F-wave parameters from the remaining late wave segments.
5 more elements
A method for submaximal F-wave acquisition and analysis, the method comprising:
- (i) applying a series of stimuli of increasing intensity to a nerve;
- (ii) recording a series of early responses;
- (iii) determining the submaximal stimulation intensity based on a percentage or magnitude reduction of the supramaximal stimulation intensity;
- (iv) applying a series of stimuli of fixed intensity at the submaximal level to the nerve;
- (v) recording a series of late responses;
- (vi) detecting possible A-wave and H-reflex responses and excluding those waveform segments from the late responses;
- and
- (vii) extracting F-wave parameters from the remaining late wave segments.
5 more elements
A method for submaximal F-wave acquisition and analysis, the method comprising:
- (i) applying a series of stimuli of increasing intensity to a nerve;
- (ii) recording a series of early responses;
- (iii) determining the submaximal stimulation intensity based on a percentage or magnitude reduction of the supramaximal early response magnitude;
- (iv) applying a series of stimuli of fixed intensity at the submaximal level to the nerve;
- (v) recording a series of late responses;
- (vi) detecting possible A-wave and H-reflex responses and excluding those waveform segments from the late responses;
- (vii) applying a series of stimuli with an increased level of intensity capable of suppressing axon-reflex and/or H-reflex in the late responses;
- (viii) recording a series of late responses;
- and
- (ix) determining the F-wave characteristics based on the late responses.
7 more elements
A method for submaximal F-wave acquisition and analysis, the method comprising:
- (i) applying a series of stimuli of increasing intensity to a nerve;
- (ii) recording a series of early responses;
- (iii) determining the submaximal stimulation intensity based on a stimulus response curve and a target ratio between the submaximal and supramaximal early response magnitudes;
- (iv) applying a series of stimuli of fixed intensity at the submaximal level to the nerve;
- (v) recording a series of late responses;
- (vi) detecting possible A-wave and H-reflex responses and excluding those waveform segments from the late responses;
- (vii) extracting F-wave features from the late responses;
- (viii) applying a series of stimuli of fixed intensity at a higher level to the nerve;
- (ix) recording a series of late responses;
- (x) detecting possible A-wave and H-reflex responses and excluding those waveform segments from the late responses;
- (xi) extracting F-wave features from the late responses;
- and
- (xii) conducting a comparison analysis of F-wave features from lower and higher stimulation intensities.
10 more elements
A method for acquiring submaximal F-wave features, comprising:
- (i) determining the stimulation intensity levels for submaximal F-wave acquisition;
- (ii) acquiring and analyzing late waves under submaximal stimulation conditions;
- (iii) modifying the stimulation conditions based on real-time monitoring of the late wave analysis outcomes;
- and
- (iv) extracting and comparing F-wave features under alternative stimulation conditions.
2 more elements
Apparatus for acquiring submaximal F-wave features, comprising:
- (i) a unit for determining the stimulation intensity levels for submaximal F-wave acquisition;
- (ii) a unit for acquiring and analyzing late waves under submaximal stimulation conditions;
- (iii) a unit for modifying the stimulation conditions based on real-time monitoring of the late wave analysis outcomes;
- and
- (iv) a unit for extracting and comparing F-wave features under alternative stimulation conditions.
2 more elements
Dependencies are inferred from the claim text.