Amino ceramide-like compounds and therapeutic methods of use
OwnerJames Shaymaninventor
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Abstract
Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
Claims22
A compound selected from the group consisting of the formula:
- wherein R1 is an aromatic structure, an alicylic structure, a branched aliphatic structure or a linear aliphatic group having 5 to 15 carbons;
- R2 is an aliphatic chain having 6, 7 and 8 carbons;
- R3 is a tertiary amine;
- and
- R4 is a group that is selectively hydrolyzed in a target cell.
(canceled)
8-11. (canceled)
A compound selected from the group consisting of the formula:
- R2 is an aliphatic chain having 6, 7 and 8 carbons;
- R3 is a tertiary amine;
- R4 is a group that is selectively hydrolyzed in a target cell or a hydrogen;
- and
- R6 is a group that is selectively hydrolyzed in a target cell.
(canceled)
20-23. (canceled)
A compound selected from the group of the formulas:
- wherein R2 is an aliphatic chain having 6, 7 and 8 carbons;
- n is an integer from 1 to 19;
- and
- R3 is a tertiary amine.
(canceled)
28-31. (canceled)
Dependencies are inferred from the claim text.