Preparation of cabergoline
OwnerParveen Bhatarah, Derek McHattie +2inventors
InventorsParveen Bhatarah, Derek McHattie, Alan Greenwood, Paul Hedger
Life of this patent
Estimating the term…
Abstract
A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and 4-fluorotoluene or 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a method for preparing cabergoline Form I comprising dissolving cabergoline in 4-fluorotoluene or 1,3,5-trimethylbenzene and recovering the cabergoline Form 1 polymorph. Cabergoline Form I can then be obtained from the solution, suitably by direct crystallization of Form I or by recovery of a solvate which can be converted to Form I.
Claims72
A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and 4-fluorotoluene and obtaining cabergoline Form I from the solvate.
A solvate form of cabergoline comprising cabergoline and 4-fluorotoluene.
A method of preparing cabergoline Form I comprising dissolving cabergoline in a first solvent comprising 4-fluorotoluene to form a solution and obtaining cabergoline Form I from the solution.
A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate.
A solvate form of cabergoline comprising cabergoline and 1,3,5-trimethylbenzene.
A method of preparing cabergoline Form I comprising dissolving cabergoline in a first solvent comprising 1,3,5-trimethylbenzene to form a solution and obtaining Form I cabergoline from the solution.
Dependencies are inferred from the claim text.