Degradable polymers and methods of preparation thereof
AssigneeWright Davis Biomedical Technologies, Inc.
InventorsMark Davis, Kenneth Wright, Ryan Zeidan
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Abstract
The present invention provides polymers which substantially degrade in the presence of one or more triggers, preferably light energy or hydrogen peroxide, but does not substantially degrade in the absence of one or more triggers.
Claims67
A biocompatible polymer, wherein the polymer substantially degrades in the presence of one or more triggers but does not substantially degrade under physiological conditions in the absence of one or more triggers.
A method for the degradation of a polymer in a patient, comprising:
- a) subjecting the polymer to an amount of a first trigger;
- and
- b) subjecting the polymer to an amount of a second trigger in the presence of the first trigger;
- thereby degrading the polymer in the patient,
- wherein the polymer substantially degrades in the presence of both the first and second trigger, and the polymer does not substantially degrade in the presence of either the first or second trigger alone.
A method for the preparation of a polymer according to Formula III:
- comprising reacting a monomer of Formula A with a monomer of Formula B or a monomer of Formula C under reaction conditions:
- thereby preparing the polymer of Formula III, wherein,
- Ar, independently for each occurrence, is an aryl or heteroaryl group;
- U is O or S;
- X is a leaving group;
- Y is NR″, S, or O;
- L is a linking group;
- R″ is H or lower alkyl;
- and
- m is an integer greater than 10.
The method of claim 63, wherein the base is an amine base.
The method of claim 64, wherein the base is pyridine.
Dependencies are inferred from the claim text.