TGF-beta modulators and methods for using the same
OwnerJames Burmesterinventor
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Abstract
The present invention provides a method of modulating TGF-β activity in a subject. Methods of the present invention comprise administering to the subject an effective amount of a compound of the formula: or a salt, prodrug, tautomer, hydrate, solvate, or stereoisomer thereof, wherein a is an integer from 0 to 4; each R1 is independently hydroxy, alkoxy, halide, alkyl, cyano, nitro, amino, monoalkylamino, dialkylamino, or carboxy; R2 is aryl, cycloalkyl, alkenyl, or alkyl, each of which is optionally substituted; each of X1 and X2 is independently O, S or NR, wherein R3is hydrogen or alkyl; X3 is hydrogen, alkoxy, alkyl, hydroxy, halide, amino, monoalkylamino, or dialkylamino; and X4 is alkoxy, hydroxy, halide, amino, monoalkylamino, or dialkylamino.
Claims17
A method of modulating TGF-β activity in a subject comprising administering to the subject an effective amount of a compound of the formula:
- or a salt, prodrug, tautomer, hydrate, solvate, or stereoisomer thereof, wherein
- a is an integer from 0 to 4;
- each R1 is independently hydroxy, alkoxy, halide, alkyl, cyano, nitro, amino, monoalkylamino, dialkylamino, or carboxy;
- R2 is aryl, cycloalkyl, alkenyl, or alkyl, each of which is optionally substituted;
- each of X1 and X2 is independently O, S or NR3,
- wherein
- R3is hydrogen or alkyl;
- X3 is hydrogen, alkoxy, alkyl, hydroxy, halide, amino, monoalkylamino, or dialkylamino;
- and
- X4 is alkoxy, hydroxy, halide, amino, monoalkylamino, or dialkylamino.
A method of treating a TGF-mediated disease comprising administering to a patient suffering from a TGF-mediated disease a therapeutically effective amount of a TGF-β antagonist.
A method for stimulating a patient's immune system, said method comprising administering a therapeutically effective amount of a TGF-β antagonist to the patient.
A method for reducing a risk of cancer in a subject, said method comprising administering a therapeutically effective amount of a TGF-β modulator to the subject to significantly reduce the TGF-β activity.
Dependencies are inferred from the claim text.