Process for the preparation of docetaxel trihydrate

A method to prepare Docetaxel trihydrate, where in the method is:

• under temperature of 10-39° C., put anhydrous Docetaxel (purity of HPLC>99.5%) in 8˜12 parts acetone to fully dissolve. Then under the same temperature, and reduced pressure concentrate it to form oil-like matter, add certain quantity of acetone to fully dissolve, concentrate in reduced pressure again to form oil-like matter, then add certain quantity of acetone to fully dissolve, add dropwise certain quantity of purified water, the procedure will last 10˜60 min. Control the dropping speed to avoid the growth of agglomeration during the process. Then cool the product under 0° C. for 2-5 hours, filter by suction, then wash the residue cake with the mixture of acetone and water (1:1˜1:5), dry on P2O5 in vacuum till the weight is constant, the product obtained is Docetaxel trihydrate.