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US 2006/0217434 A1Published application
Remedy for viral disease
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsMasahiro Aoki, Hideyuki Kato, Masayuki Sudoh, Takuo Tsukuda, Miyako Masubuchi, Kenichi Kawasaki
Life of this patent
Estimating the term…
Abstract
The object of the present invention is to provide a pharmaceutical composition for preventing or treating viral infectious diseases. The compounds of the present invention have extremely potent anti-HCV activity and HCV growth inhibitory effects, and since they also only demonstrate mild cytotoxicity in vivo, a pharmaceutical composition containing the compound of the present invention is extremely useful as an anti-HCV preventive/therapeutic agent.
Claims24
A pharmaceutical composition for preventing or treating viral infectious diseases comprising a compound represented by the following general formula (I):
- wherein
- A represents a phenyl group substituted with —OX, or a 3-indolyl group;
- X represents a hydrogen atom, a linear or branched alkyl group having 1 to 8 carbon atoms, a linear or branched alkenyl group having 2 to 8 carbon atoms, or a linear or branched alkynyl group having 2 to 8 carbon atoms;
- B represents a hydrogen atom, a hydroxyl group, an oxo group, —N(R4)(R5), ═N—OH, ═N—OR6 or a halogen atom;
- R4 and R5 may be the same or different, and each represent a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, a linear or branched alkenyl group having 2 to 6 carbon atoms, or a linear or branched alkynyl group having 2 to 6 carbon atoms, or R4 and R5 together represent a 3 to 8 membered ring;
- R6 represents a linear or branched alkyl group having 1 to 8 carbon atoms (which may be substituted with an amino group which may be mono- or di-substituted with a linear or branched alkyl group having 1 to 4 carbon atoms);
- D represents a hydrogen atom or a hydroxyl group;
- bond E represents a single bond or double bond;
- R1, R2 and R3 may be the same or different, and each represent a hydrogen atom, a hydroxyl group, an amino group (which may be mono- or di-substituted with a linear or branched alkyl group having 1 to 4 carbon atoms), —OZ, a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkenyl group having 2 to 4 carbon atoms, or a linear or branched alkynyl group having 2 to 4 carbon atoms;
- and,
- Z represents a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkenyl group having 2 to 4 carbon atoms, or a linear or branched alkynyl group having 2 to 4 carbon atoms;
- a prodrug thereof or a pharmaceutically acceptable salt thereof.
9 more elements
A compound represented by the following general formula (I):
- wherein
- A represents a phenyl group substituted with —OX;
- X represents a hydrogen atom, a linear or branched alkyl group having 1 to 8 carbon atoms, a linear or branched alkenyl group having 2 to 8 carbon atoms, or a linear or branched alkynyl group having 2 to 8 carbon atoms;
- B represents a hydrogen atom, a hydroxyl group, an oxo group, —N(R4)(R5), ═N—OH, ═N—OR6 or a halogen atom;
- R4 and R5 may be the same or different, and each represent a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, a linear or branched alkenyl group having 2 to 6 carbon atoms, or a linear or branched alkynyl group having 2 to 6 carbon atoms, or R4 and R5 together represent a 3 to 8 membered ring;
- R6 represents a linear or branched alkyl group having 1 to 8 carbon atoms (which may be substituted with an amino group which may be mono- or di-substituted with a linear or branched alkyl group having 1 to 4 carbon atoms;
- D represents a hydrogen atom or a hydroxyl group;
- bond E represents a single bond or double bond;
- R1, R2 and R3 may be the same or different, and each represent a hydrogen atom, a hydroxyl group, an amino group (which may be mono- or di-substituted with a linear or branched alkyl group having 1 to 4 carbon, atoms), —OZ, a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkenyl group having 2 to 4 carbon atoms, or a linear or branched alkynyl group having 2 to 4 carbon atoms;
- and,
- Z represents a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkenyl group having 2 to 4 carbon atoms, or a linear or branched alkynyl group having 2 to 4 carbon atoms, with the proviso that the case in which A is a phenyl group substituted with —OX at the p position, X is a 2-isopentenyl group or a hydrogen atom, B is an oxo group, D is a hydrogen atom, E represents a double bond, and all of R1 to R3 are a hydroxyl group, and the case in which A is a phenyl group substituted with —OX at position p, X is a 2-isopentenyl group, B is an oxo group, D is a hydrogen atom, bond E represents a double bond, and all of R1 to R3 are a methoxy group are excluded)
- a prodrug thereof or a pharmaceutically acceptable salt thereof.
9 more elements
A compound represented by the following general formula (I):
- wherein
- A represents a phenyl group substituted with —OX;
- X represents a hydrogen atom, a linear or branched alkyl group having 1 to 8 carbon atoms, a linear or branched alkenyl group having 2 to 8 carbon atoms, or a linear or branched alkynyl group having 2 to 8 carbon atoms;
- B represents a hydrogen atom, a hydroxyl group, an oxo group, —N(R4)(R5), ═N—OH, ═N—OR6 or a halogen atom;
- R4 and R5 may be the same or different, and each represent a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, a linear or branched alkenyl group having 2 to 6 carbon atoms, or a linear or branched alkynyl group having 2 to 6 carbon atoms, or R4 and R5 together represent a 3 to 8 membered ring;
- R6 represents a linear or branched alkyl group having 1 to 8 carbon atoms (which may be substituted with an amino group which may be mono- or di-substituted with a linear or branched alkyl group having 1 to 4 carbon atoms;
- D represents a hydrogen atom or a hydroxyl group;
- bond E represents a single bond or double bond;
- R1, R2 and R3 may be the same or different, and each represent a hydrogen atom, a hydroxyl group, an amino group (which may be mono- or di-substituted with a linear or branched alkyl group having 1 to 4 carbon atoms), —OZ, a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkenyl group having 2 to 4 carbon atoms, or a linear or branched alkynyl group having 2 to 4 carbon atoms;
- and,
- Z represents a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkenyl group having 2 to 4 carbon atoms, or a linear or branched alkynyl group having 2 to 4 carbon atoms, with the proviso that the case in which A is a phenyl group substituted with —OX at position p and X is a hydrogen atom, and the case in which A is a phenyl group substituted with —OX at position p, X is a 2-isopentenyl group, B is an oxo group, D is a hydrogen atom, bond E indicates a double bond, and all of R1 to R3 are a hydroxyl group or a methoxy group are excluded;
- a prodrug thereof or a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.