Sulfonamide derivatives as ppar modulators

A compound having a structural Formula II,

• and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, wherein:
• Q is:
• —C(O)OR6 or R6A;
• X is:
• a bond, C, O, S or S[O]p;
• Y is:
• a bond, S, C or O;
• Z is:
• a) aliphatic group,
• b) aryl,
• c) a 5- to 10-membered heteroaryl wherein the heteroaryl containing at least one heteroatom selected from N, O or S,
• d) bi-aryl, wherein biaryl being defined as aryl substituted with another aryl or aryl substituted with heteroaryl,
• e) bi-heteroaryl, wherein bi-heteroaryl being defined as heteroaryl substituted with another heteroaryl, or heteroaryl substituted with aryl, and
• f) heterocyclyl;
• wherein aliphatic group, aryl, heteroaryl, bi-aryl, bi-heteroaryl and heterocyclyl being optionally substituted with one or more groups independently selected from R15;
• m and n′ are each independently:
• 0, 1, 2, 3 or 4;
• n is:
• 0, 1, 2 or 3;
• p is:
• 1 or 2;
• r is:
• 1, 2, 3 or 4;
• R1 is:
• aryl,
• haloalkyl,
• C1-C6 alkyl,
• C1-C6 alkyl-C1-C6 alkoxy,
• C1-C6 alkyl-aryl,
• C2-C6 alkenyl,
• C2-C6 alkynyl,
• (CH2)n.C3-C6 cycloalkyl,
• C1-C6 alkoxy or
• R1 and R2 together being a 5- to 8′-membered heterocyclyl ring, and wherein alkyl, aryl, alkenyl, alkynyl, cycloalkyl and alkoxy being optionally substituted with one or more groups independently selected from R15;
• R1a and R1b are each independently:
• hydrogen,
• C1-C6 alkyl, or
• R1 and R1a, R1 and R1b, R2 and R1a, R2 and R1b or R1a and R1b together being a 3- to 6-membered heterocyclyl or carbocyclyl ring where at least one of R1a and R1b is not hydrogen;
• R2 is:
• hydrogen,
• haloalkyl,
• C1-C6 alkyl,
• C1-C6 alkyl-C1-C6 alkoxy,
• C1-C6 alkyl-aryl,
• C2-C6 alkenyl,
• C2-C6 alkynyl,
• (CH2)n.C3-C6 cycloalkyl,
• C1-C6 alkoxy,
• aryl, or
• R1 and R2 together being a 5- to 8-membered heterocyclyl ring, and
• wherein alkyl, aryl, alkenyl, alkynyl, cycloalkyl and alkoxy being optionally substituted with one or more groups independently selected from R15;
• R2a is:
• hydrogen, halo or C1-C6 alkyl and wherein R2 and R2a together being a 3- to 8-membered ring;
• and wherein alkyl being optionally substituted with one or more groups independently selected from R15;
• R3 is:
• hydrogen,
• halo,
• cyano,
• haloalkyl,
• C1-C6 alkyl,
• (CH2)n.C3-C6 cycloalkyl,
• (C1-C4 alkyl)-heterocyclyl, wherein the heterocyclyl being optionally substituted with oxo,
• (C1-C4 alkyl)-NR7C(O)pR9, and
• wherein alkyl, cycloalkyl and heterocyclyl being optionally substituted with one or more groups independently selected from R15;
• R4 and R5 are each independently:
• hydrogen,
• halo,
• C1-C6 alkyl
• C1-C6 alkoxy;
• aryloxy;
• N(R8)2,
• SR8 or
• R4 and R5 together being a 3- to 8-membered ring;
• R6 is:
• hydrogen, C1-C6 alkyl or aminoalkyl;
• R6A is:
• carboxamide, C1-C3 alkylnitrile, sulfonamide, acylsulfonamide or tetrazole;
• R7 is:
• hydrogen or C1-C6 alkyl;
• R8 and R9 are each independently:
• hydrogen, C1-C6 alkyl, aryl, heteroaryl, or heterocyclyl, and
• wherein aryl, heteroaryl and heterocyclyl being optionally substituted with one or more substituents selected from the group consisting of hydrogen, nitro, cyano, hydroxyl, halo, haloalkyl, haloalkyloxy, aryloxy, oxo, C1-C6 alkyl and C1-C6 alkoxy;
• R15 is:
• hydrogen, nitro, cyano, hydroxyl, halo, haloalkyl, haloalkyloxy, aryloxy, oxo, C1-C6 alkyl, C1-C6 alkoxy, (CH2)n.C3-C6 cycloalkyl, N(R8)2, NR8S(O)2R9, NR8C(O)pR9, C(O)NR8R9, C(O)pR8, SR8, S(O)pR8 or S(O)2NR8R9.

A compound having a structural Formula VI,

• and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, wherein:
• X is:
• a bond, C, O, S or S[O]p;
• Y is:
• a bond, S, C or O;
• Z is:
• heteroaryl wherein the heteroaryl containing at least one heteroatom selected from N, O or S, and wherein heteroaryl being optionally substituted with one or more groups selected from R15;
• n is:
• 0, 1, 2 or 3;
• n′ is:
• 0, 1, 2, 3 or 4;
• p is:
• 1 or 2;
• r is:
• 1, 2, 3 or 4;
• R1 is:
• hydrogen,
• haloalkyl,
• C1-C6 alkyl,
• C1-C6 alkyl-C1-C6 alkoxy,
• C1-C6 alkyl-aryl,
• C2-C6 alkenyl,
• C2-C6 alkynyl,
• (CH2)n.C3-C6 cycloalkyl,
• C1-C6 alkoxy,
• aryl, or
• R1 and R2 together being a 5- to 8-membered heterocyclyl ring, and
• wherein alkyl, aryl, alkenyl, alkynyl, cycloalkyl and alkoxy being optionally substituted with one or more groups independently selected from R15;
• R1a and R1b are each independently:
• hydrogen,
• C1-C6 alkyl, or
• R1 and R1a, R1 and R1b, R2 and R1a, R2 and R1b or R1a and R1b together being a 3- to 6-membered heterocyclyl or carbocyclyl ring where at least one of R1a and R1b is not hydrogen;
• R2 is:
• hydrogen,
• haloalkyl,
• C1-C6 alkyl,
• C1-C6 alkyl-C1-C6 alkoxy,
• C1-C6 alkyl-aryl,
• C2-C6 alkenyl,
• C2-C6 alkynyl,
• (CH2)n.C3-C6 cycloalkyl,
• C1-C6 alkoxy,
• aryl, or
• R1 and R2 together being a 5- to 8-membered heterocyclyl ring, and
• wherein alkyl, aryl, alkenyl, alkynyl, cycloalkyl and alkoxy being optionally substituted with one or more groups independently selected from R15;
• R2a is:
• hydrogen, halo or C1-C6 alkyl and wherein R2 and R2a together being a 3- to 8-membered ring;
• and wherein alkyl being optionally substituted with one or more groups independently selected from R15;
• R3 is:
• hydrogen,
• halo,
• cyano,
• haloalkyl,
• C1-C6 alkyl,
• (CH2)n.C3-C6 cycloalkyl,
• (C1-C4 alkyl)-heterocyclyl, wherein the heterocyclyl being optionally substituted with oxo,
• (C1-C4 alkyl)-NR7C(O)pR9, and
• wherein alkyl, cycloalkyl and heterocyclyl being optionally substituted with one or more groups independently selected from R15;
• R6 is:
• hydrogen, C1-C6 alkyl or aminoalkyl;
• R7 is:
• hydrogen or C1-C6alkyl;
• R8 and R9 are each independently:
• hydrogen, C1-C6 alkyl, aryl, heteroaryl, or heterocyclyl, and
• wherein aryl, heteroaryl and heterocyclyl being optionally substituted with one or more substituents selected from the group consisting of hydrogen, nitro, cyano, hydroxyl, halo, haloalkyl, haloalkyloxy, aryloxy, oxo, C1-C6 alkyl and C1-C6 alkoxy;
• and
• R15 is:
• hydrogen, nitro, cyano, hydroxyl, halo, haloalkyl, haloalkyloxy, aryloxy, oxo, C1-C6 alkyl, C1-C6 alkoxy, N(R8)2, NR8S(O)2R9, NR8C(O)pR9, C(O)NR8R9, C(O)pR8, SR9, S(O)pR8 or S(O)2NR8R9.

A compound having a structural Formula IX,

• and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, wherein:
• E is:
• O, S or NR14;
• W is:
• hydrogen, C1-C6 alkyl, (CH2)n.C3-C6 cycloalkyl, haloalkyl or acyl;
• Q is:
• —C(O)OR6 or R6A;
• X is:
• a bond, C, O, S or S[O]p;
• Y is:
• a bond, S, C or O;
• Z is:
• a) aliphatic group,
• b) aryl,
• c) a 5- to 10-membered heteroaryl wherein the heteroaryl containing at least one heteroatom selected from N, O or S,
• d) bi-aryl, wherein biaryl being defined as aryl substituted with another aryl or aryl substituted with heteroaryl,
• e) bi-heteroaryl, wherein bi-heteroaryl being defined as heteroaryl substituted with another heteroaryl, or heteroaryl substituted with aryl, and
• f) heterocyclyl;
• wherein aliphatic group, aryl, heteroaryl, bi-aryl, bi-heteroaryl and heterocyclyl being optionally substituted with one or more groups independently selected from R15;
• m and n′ are each independently:
• 0, 1, 2, 3 or 4;
• n is:
• 0, 1, 2 or 3;
• p is:
• 1 or 2;
• r is:
• 1, 2, 3 or 4;
• v is:
• 1 or 2;
• R1 is:
• hydrogen,
• haloalkyl,
• C1-C6 alkyl,
• C1-C6 alkyl-C1-C6 alkoxy,
• C1-C6 alkyl-aryl,
• C2-C6 alkenyl,
• C2-C6 alkynyl,
• (CH2)n.C3-C6 cycloalkyl,
• C1-C6 alkoxy,
• aryl, or
• R1 and R2 together being a 5- to 8-membered heterocyclyl ring, and
• wherein alkyl, aryl, alkenyl, alkynyl, cycloalkyl and alkoxy being optionally substituted with one or more groups independently selected from R15;
• R1a and R1b are each independently:
• hydrogen,
• C1-C6 alkyl, or
• R1 and R1a, R1 and R1b, R2 and R1a, R2 and R1b or R1a and R1b together being a 3- to 6-membered heterocyclyl or carbocyclyl ring where at least one of R1a and R1b is not hydrogen;
• R2 is:
• hydrogen,
• haloalkyl,
• C1-C6 alkyl,
• C1-C6 alkyl-C1-C6 alkoxy,
• C1-C6 alkyl-aryl,
• C2-C6 alkenyl,
• C2-C6 alkynyl,
• (CH2)n.C3-C6 cycloalkyl,
• C1-C6 alkoxy,
• aryl, or
• R1 and R2 together being a 5- to 8-membered heterocyclyl ring, and
• wherein alkyl, aryl, alkenyl, alkynyl, cycloalkyl and alkoxy being optionally substituted with one or more groups independently selected from R15;
• R2a is:
• hydrogen, halo or C1-C6 alkyl and wherein R2 and R2a together being a 3- to 8-membered ring;
• and wherein alkyl being optionally substituted with one or more groups independently selected from R15;
• R3 is:
• hydrogen,
• halo,
• cyano,
• haloalkyl,
• C1-C6 alkyl,
• (CH2)n.C3-C6 cycloalkyl,
• (C1-C4 alkyl)-heterocyclyl, wherein the heterocyclyl being optionally substituted with oxo,
• (C1-C4 alkyl)-NR7C(O)pR9, and
• wherein alkyl, cycloalkyl and heterocyclyl being optionally substituted with one or more groups independently selected from R15;
• R4 and R5 are each independently:
• hydrogen,
• halo,
• C1-C6 alkyl
• C1-C6 alkoxy;
• aryloxy;
• N(R8)2,
• SR8 or
• R4 and R5 together being a 3- to 8-membered ring;
• R6 is:
• hydrogen, C1-C6 alkyl or aminoalkyl;
• R6A is:
• carboxamide, C1-C3 alkylnitrile, sulfonamide, acylsulfonamide or tetrazole;
• R7 is:
• hydrogen or C1-C6alkyl;
• R8 and R9 are each independently:
• hydrogen, C1-C6 alkyl, aryl, heteroaryl, or heterocyclyl, and
• wherein aryl, heteroaryl and heterocyclyl being optionally substituted with one or more substituents selected from the group consisting of hydrogen, nitro, cyano, hydroxyl, halo, haloalkyl, haloalkyloxy, aryloxy, oxo, C1-C6 alkyl and C1-C6 alkoxy;
• R14 is:
• hydrogen, aryl, C1-C6 alkyl, or C1-C6 alkyl-COOR6, and
• wherein aryl and alkyl being optionally substituted with one or more groups independently selected from R15;
• and
• R15 is:
• hydrogen, nitro, cyano, hydroxyl, halo, haloalkyl, haloalkyloxy, aryloxy, oxo, C1-C6 alkyl, C1-C6 alkoxy, (CH2)n.C3-C6 cycloalkyl, N(R8)2, NR8S(O)2R9, NR8C(O)pR9, C(O)NR8R9, C(O)pR8, SR8, S(O)pR8 or S(O)2NR8R9.

A compound selected from the group consisting of No. 1-120 and 121:

• No.
• Structure
• Name
• 1
• 3-(4-{2-[(5-Fluoro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenyl)- propionic acid
• 2
• 3-(4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenyl)- propionic acid
• 3
• (4-{2-[(5-Chloro-3- methyl-benzofuran-2- sulfonyl)-propyl- amino]-1-methyl- ethoxy}-2-methyl- phenoxy)-acetic acid
• 4
• (4-{2-[(5-Chloro-3- methyl-benzofuran-2- sulfonyl)-propyl- amino]-1-methyl- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 5
• 3-(4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl-ethylsulfanyl}-2- methyl-phenyl)-propionic acid
• 6
• (4-{2-[(5-Chloro-3- ethyl-benzo[b]thiophene-2- sulfonyl)-propyl amino]-1-methyl- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 7
• 4-{2-[(6-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 8
• 4-{2-[(7-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 9
• (4-{2-[(4-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 10
• (4-{2-[(5-Chloro-3- trifluoromethyl- benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 11
• (4-{2-[(5-Chloro-3- trifluoromethyl- benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl- ethoxy}-2-methyl- phenoxy)-acetic acid
• 12
• 2-[4-(3-{[5-(4′-Fluoro- biphenyl-4-yl)- thiophene-2-sulfonyl]- propyl-amino}-propyl)- phenoxy]-2-methyl- propionic acid
• 13
• 2-(4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propy]- amino]-ethyl}- phenoxy)-2-methyl- propionic acid
• 14
• 2-(4-{3-[(3,5-Dimethyl- benzo[b]thiophene-2- sulfonyl)-propyl- amino]-propyl}- phenoxy)-2-methyl- propionic acid
• 15
• 2-(4-{3-[(5-Fluoro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-propyl}- phenoxy)-2-methyl- propionic acid
• 16
• 2-(4-{3-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-(2,2,2- trifluoro-ethyl)-amino]- propyl}-phenoxy)-2- methyl-propionic acid
• 17
• 2-(4-{2-[(3-Ethyl- benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethoxy}-3- propyl-phenoxy)-2- methyl-propionic acid
• 18
• 2-[4-(1-{[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propoxy)-2-methyl- phenoxy]-2-methyl- propionic acid
• 19
• 3-[4-(1-{[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propoxy)-2-methyl- phenyl]-propionic acid
• 20
• [4-(1-{[(5-Fluoro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propylsulfanyl)-2- methyl-phenoxy]-acetic acid
• 21
• [4-(1-{[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propylsulfanyl)-2- methyl-phenoxy]-acetic acid
• 22
• [4-(1-{[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propylsulfanyl)-2- methyl-phenoxy]-acetic acid
• 23
• (2-Methyl-4-{2-[(6- phenoxy-pyridine-3- sulfonyl)-propyl- amino]-ethylsulfanyl}phenoxy)-acetic acid
• 24
• (2-Methyl-4-{2-[(5- methyl-1-phenyl-1H- pyrazole-4-sulfonyl)- propyl-amino]- ethylsulfanyl}- phenoxy)-acetic acid
• 25
• (2-Methyl-4-{2-[(4- oxazol-5-yl-benzenesulfonyl)- propyl-amino]- ethylsulfanyl}- phenoxy)-acetic acid
• 26
• (2-Methyl-4-{2-[propyl- (4-pyrazol-1-yl- benzenesulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 27
• (2-Methyl-4-{2-[(2- naphthalen-1-yl- ethanesulfonyl)-propyl- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 28
• (2-Methyl-4-{2-[propyl- (4-trifluoromethylphenyl- methanesulfonyl)-amino]- ethylsulfanyl)- phenoxy)-acetic acid
• 29
• (4-{2-[(Biphenyl-3- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 30
• (4-{2-[(2,3-Dihydro- benzo[1,4]dioxine-6- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 31
• [2-Methyl-4-(2-{[5-(2- methylsulfanyl-pyrimidin-4-yl)- thiophene-2-sulfonyl]- propyl-amino}- ethylsulfanyl)- phenoxy]-acetic acid
• 32
• [2-Methyl-4-(2-{[5-(1- methyl-5-trifluoromethyl-1H- pyrazol-3-yl)-thiophene- 2-sulfonyl]-propyl- amino}-ethylsulfanyl)- phenoxy]-acetic acid
• 33
• [2-Methyl-4-(2-{[5-(1- methyl-3-trifluoromethyl-1H- pyrazol-4-yl)-thiophene- 2-sulfonyl]-propyl- amino}-ethylsulfanyl)- phenoxy]-acetic acid
• 34
• (R)-(2-Methyl-4-{1- methyl-2-[(3-methyl-5- trifluoromethyl- benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 35
• (R)-3-(4-{2-[(6-Chloro- 5-fluoro-3-methyl- benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl- ethylsulfanyl}-2- methyl-phenyl)-propionic acid
• 36
• (R)-(4-{2-[(6-Chloro-5- fluoro-3-methyl- benzo[b]thiophene-2- sulfony])-propyl- amino]-1-methyl- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 37
• (4-{2-[(4-Bromo- benzenesulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 38
• (4-{2-[(3,4-Dichloro- benzenesulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 39
• (4-{2-[(4-Isopropyl- benzenesulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 40
• (2-Methyl-4-{2-[(4- pentyl-benzenesulfonyl)- propyl-amino]- ethylsulfanyl}- phenoxy)-acetic acid
• 41
• (4-{2-[(2-Chloro-4- trifluoromethyl- benzenesulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 42
• (2-Methyl-4-{2-[propyl- (3-trifluoromethyl- benzenesulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 43
• (4-{2-[(4-Bromo-2- methyl-benzenesulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 44
• (4-{2-[(3,4-Dibromo- benzenesulfonyl)- propyl-amino]-ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 45
• (2-Methyl-4-{2-[propyl- (4-propyl-benzenesulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 46
• (4-{2-[(2,4-Dichloro- benzenesulfonyl)-propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 47
• (4-{2-[(4-Iodo- benzenesulfonyl)- propyl-amino]-ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 48
• (4-{2-[(3-Chloro-4- methyl-benzenesulfonyl)- propyl-amino]- ethylsulfanyl}2- methyl-phenoxy)-acetic acid
• 49
• (4-{2-[(4-Bromo-2,5- difluoro-benzenesulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 50
• (2-Methyl-4-{1-methyl- 2-[propyl-(4-trifluoromethyl- benzenesulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 51
• (4-{2-[(3,4-Dichloro- benzenesulfonyl)- propyl-amino]-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 52
• (2-Methyl-4-{2-[propyl- (2′-trifluoromethyl- biphenyl-4-sulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 53
• (2-Methyl-4-{2-[propyl- (3′-trifluoromethyl- biphenyl-4-sulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 54
• (2-Methyl-4-{2-[propyl- (4′-trifluoromethyl- biphenyl-4-sulfony])- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 55
• (4-{2-[(2′-Fluoro- biphenyl-4-sulfonyl)- propyl-amino]- ethyl sulfanyl}-2- methyl-phenoxy)-acetic acid
• 56
• (4-{2-[(4′-Fluoro- biphenyl-4-sulfonyl)- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 57
• (2-Methyl-4-{2-[propyl- (4′-trifluoromethoxy- biphenyl-4-sulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 58
• (4-{2-[(3′,4′-Dichloro- biphenyl-4-sulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 59
• (4-{2-[(3′-Fluoro- biphenyl-4-sulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 60
• (4-{2-[(2′-Chloro- biphenyl-4-sulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 61
• (4-{2-[(4′-Methoxy- biphenyl-4-sulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 62
• (4-{2-[(4′-Methoxy- biphenyl-4-sulfonyl)- propyl-amino]-ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 63
• (4-{2-[(3′-Chloro-4′- fluoro-bipheny]-4- sulfonyl)-propyl]- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 64
• (4-{2-[(4-Chloro-3- trifluoromethyl- benzenesulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 65
• (2-Methyl-4-{1-methyl- 2-[propyl-(4- trifluoromethoxy- benzenesulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 66
• (2-Methyl-4-{1-methyl- 2-[propyl-(4-propyl- benzenesulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 67
• (4-{2-[(4-Chloro-3- trifluoromethyl- benzenesulfonyl)- propyl-amino]-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 68
• (4-{2-[(3-Chloro-4- trifluoromethyl- benzenesulfonyl)- propyl-amino]-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 69
• (4-{2-[(4-Butyl- benzenesulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 70
• (4-{2-[(4-Isobutyl- benzenesulfonyl)-propyl-amino]- ethylsulfanyl)-2- methyl-phenoxy)-acetic acid
• 71
• (4-{2-[(2-Chloro-4- trifluoromethyl- benzenesulfonyl)- propyl-amino]-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 72
• (4-{2-[(4-Bromo-3- chloro-benzenesulfonyl)- propyl-amino}-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 73
• (4-{2-[(4-Butyl-3- chloro-benzenesulfonyl)- propyl-amino]-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 74
• (4-{2-[(3-Chloro-4- isobutyl-benzenesulfonyl)- propyl-amino]-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 75
• (4-{2-[(4-Bromo- benzenesulfonyl)- propyl-amino]-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 76
• (4-{2-[(4-Butyl- benzenesulfonyl)- propyl-amino]-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 77
• (4-{2-[(2-Chloro-4′- fluoro-biphenyl-4- sulfonyl)-propyl- amino]-1-methyl- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 78
• (4-{2-[(3-Chloro-4- propyl-benzenesulfonyl)- propyl-amino]-1- methyl-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 79
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-propyl-phenoxy)-acetic acid
• 80
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 81
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-trifluoromethyl- phenoxy)-acetic acid
• 82
• [2-Methyl-4-(1- {[propyl-(4- trifluoromethoxy- benzenesulfonyl)- amino]-methyl}- propylsulfanyl)- phenoxy]-acetic acid
• 83
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propy]- amino]-1-methyl- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 84
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 85
• (2-Methyl-4-{2-[(3- methyl-5-trifluoromethyl- benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 86
• (2-Methyl-4-{2-[propyl- (4-trifluoromethyl- benzenesulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 87
• (4-{2-[(4-Ethyl- benzenesulfonyl)- propyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 88
• (2-Methyl-4-{2-[(2- methyl-4-trifluoromethoxy- benzenesulfonyl)- propyl-amino]- ethylsulfanyl}- phenoxy)-acetic acid
• 89
• (2-Methyl-4-{2-[propyl- (4-trifluoromethoxy- benzenesulfonyl)- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 90
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 91
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-(3-methyl- butyl)-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 92
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-cyclopropyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 93
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-cyclobutyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 94
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-cyclopropylmethyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 95
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-pentyl-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 96
• (4-{2-[Butyl-(5-chloro- 3-methyl-benzo[b]thiophene-2- sulfonyl)-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 97
• (4-{2-[(Biphenyl-4- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acid
• 98
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethoxy}-2- methyl-phenylsulfanyl)- acetic acid
• 99
• (4-{3-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-propyl}-2- methyl-phenoxy)-acetic acid
• 100
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl- ethoxy}-2-methyl- phenoxy)-acetic acid
• 101
• 3-(4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl-amino]-1- methyl-ethoxy}-2-methyl- phenyl)-propionic acid
• 102
• 2-(4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl- ethoxy}-2-methyl- phenoxy)-2-methyl- propionic acid
• 103
• 3-(4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl- ethoxy}-2-methoxy- phenyl)-propionic acid
• 104
• (4-{2-[(5-Fluoro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 105
• 3-(4-{2-[(5-Fluoro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl- ethoxy}-2-methyl- phenyl)-propionic acid
• 106
• (4-{2-[(5-Fluoro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-1-methyl- ethoxy}-2-methyl- phenoxy)-acetic acid
• 107
• (2-Chloro-4-{2-[(5- chloro-3-methyl- benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 108
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl)- 2-ethyl-phenoxy)-acetic acid
• 109
• (2-Methyl-4-{2- [(naphthalene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- phenoxy)-acetic acid
• 110
• (4-{2-[(5-Fluoro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)-acetic acid
• 111
• [3-Chloro-4-(1- {[propyl-(4- trifluoromethoxy- benzenesulfonyl)- amino]-methyl}- propylsulfanyl)-phenyl]- acetic acid
• 112
• (R)-(3-Chloro-4-{2-[(5- chloro-3-methyl- benzo[b]thiophene-2- sulfonyl)-propyl-amino]-1- methyl-ethylsulfanyl}-phenyl)- acetic acid
• 113
• (3-Chloro-4-{2-[(5- chloro-3-methyl- benzo[b]thiophene-2- sulfonyl)-propyl- amino]-ethylsulfanyl}- phenyl)-acetic acid
• 114
• [4-(1-{[(5-Fluoro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propoxy)-2-methyl- phenoxy]-acetic acid
• 115
• 3-[4-(1-{[(5-Fluoro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propoxy)-2-methyl- phenyl]-propionic acid
• 116
• 3-(4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-butoxy}-2- methyl-phenyl)-propionic acid
• 117
• [4-(1-{[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propoxy)-2-methyl- phenoxy]-acetic acid
• 118
• [4-(1-{[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propoxy)-2-methoxy- phenoxy]-acetic acid
• 119
• (4-{2-[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-phenethyl- amino]-ethylsulfanyl}- 2-methyl-phenoxy)- acetic acid
• 120
• (4-{2-[Benzyl-(5- chloro-3-methyl- benzo[b]thiophene-2- sulfonyl)-amino]- ethylsulfanyl}-2- methyl-phenoxy)-acetic acid
• 121
• [4-(1-{[(5-Chloro-3- methyl-benzo[b]thiophene-2- sulfonyl)-propyl- amino]-methyl}- propylsulfanyl)-2- methyl-phenoxy]-acetic acid