Methods of treating cancer using PPAR-gamma antagonists
OwnerJack Burton, Rosalyn Blumenthalinventors
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and methods of using peroxisome proliferator-activated receptor-gamma (PPARγ) antagonists. In one embodiment, the present invention relates to compositions and methods for preparing and using such antagonist compositions. In another embodiment, the present invention provides for using PPAR-gamma antagonist compositions to treat disease such as cancer. In other embodiments, the present invention provides for using PPAR-gamma antagonist and one or more additional anti-cancer agent compositions to treat cancer.
Claims25
A method of treating a cancer in a subject, comprising administering to a subject suffering from said cancer an effective amount of a PPARγ antagonist, wherein said cancer is selected from the group consisting of pancreatic cancer, ovarian cancer, prostate cancer, renal cancer, testicular cancer, urothelial cancer, skin cancer, melanoma, colon cancer, kidney cancer, breast cancer, brain cancer and hematopoietic cancer.
A method of treating breast cancer in a subject comprising administering to said subject an effective amount of T0070907.
A method of treating a cancer in a subject, comprising administering to a subject suffering from said cancer an effective amount of a combination of GW9662 and T0070907.
A composition for treating a cancer in a subject, comprising a PPARγ antagonist and an anti-cancer agent, wherein said cancer is selected from the group consisting of pancreatic cancer, ovarian cancer, prostate cancer, renal cancer, testicular cancer, urothelial cancer skin cancer, melanoma, colon cancer, kidney cancer, breast cancer, brain cancer and hematopoietic cancer.
Dependencies are inferred from the claim text.