Compounds for the inhibition of nitric oxide synthase

A compound of formula (I)

• wherein:
• A represents a phenyl ring or A represents a C8 to 10 aromatic or partially aromatic bicyclic ring system;
• R represents C1 to 6 alkyl, C1 to 6 alkoxy, halogen, hydroxy, cyano, trifluoromethyl or NR6R7;
• R3 represents hydrogen, C1 to 6 alkyl, C2 to 6 alkenyl, C3 to 6 cycloalkyl, C1 to 6 alkylthio, C1 to 6 alkoxy, halogen, hydroxy, cyano, trifluoromethyl or NR8R9, said alkoxy group being optionally further substituted by hydroxy or by one or more fluorine atoms;
• or R3 represents phenyl or a five- or six-membered aromatic heterocyclic ring containing 1 to 3 heteroatoms independently selected from O, S and N, said phenyl or aromatic heterocyclic ring being optionally substituted by one or more substituents selected independently from halogen, C1 to 4 alkyl, C1 to 4 alkoxy, hydroxy, cyano or NR8R9, said alkyl or alkoxy group being optionally further substituted by one or more fluorine atoms;
• R4 and R5 independently represent hydrogen or C1 to 6 alkyl, said alkyl group being optionally substituted by OH, C1 to 6 alkoxy, NR10R11 or phenyl, said phenyl group being optionally further substituted by C1 to 6 alkyl, C1 to 6 alkoxy, halogen, hydroxy, cyano or NR12R13;
• R6, R7, R8, R9, R10, R11, R12 and R13 independently represent hydrogen or C1 to 6 alkyl, said alkyl group being optionally substituted by OH or C1 to 6 alkoxy;
• or the groups NR4R5, NR6R7 and NR8R9 independently represent a 4- to 7-membered saturated azacyclic ring optionally incorporating one further heteroatom selected from O or N, said ring being optionally substituted by OH, C1 to 3 hydroxyalkyl or C1 to 3 alkoxy;
• V represents cyano or nitro;
• X represents O or S(O)n;
• n represents an integer 0, 1 or 2;
• Y represents C1 to 6 alkyl;
• any one of T, U and W represents N and the other two independently represent CR2 and each R2 group independently represents hydrogen, C1 to 3 alkyl, C1 to 3 alkoxy or halogen;
• or a pharmaceutically acceptable salt thereof.