Substituted sulfoxide compounds, methods for preparing the same and use thereof
OwnerJingen Deng, Qin Yang +5inventors
InventorsJingen Deng, Qin Yang, Yongle Chen, Jin Zhu, Qiwei Wang, Qiuya Huang, Xuemei Hou
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Abstract
Disclosed are an optically pure compound having formula I, its pharmaceutically acceptable salt and its pharmaceutically acceptable solvate, and a use thereof in manufacturing medicaments and pharmaceutical compositions. A process for preparing the compound defined therein is also provided.
Claims17
An optically pure compound of formula I,
- its pharmaceutically acceptable salt and its pharmaceutically acceptable solvate.
Use of an optically pure compound of formula I,
- its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate in manufacturing medicaments or pharmaceutical compositions.
A pharmaceutical composition, comprising a therapeutically effective amount of an optically pure compound of formula I,
- its pharmaceutically acceptable salt, its pharmaceutically acceptable solvate or a mixture thereof, and a pharmaceutically acceptable carrier.
A compound having formula III,
A process for preparing a compound having formula III, comprising reacting a compound of formula V with a compound of formula VI,
A process for preparing an optically pure compound of formula I, comprising oxidizing a pro-chiral sulphide of formula II in chloroform in the presence of an oxidant,
A method for treating a disease associated with excessive gastric acid in a subject, comprising administering to the subject a therapeutically effective amount of an optically pure compound of formula I,
- its pharmaceutically acceptable salt, its pharmaceutically acceptable solvate or a mixture thereof.
Dependencies are inferred from the claim text.