4-Ring imidazole derivatives as modulators of metabotropic glutamate receptor-5

A compound represented by Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• X and Y each independently is aryl or heteroaryl wherein at least one of X and Y is a heteroaryl with N adjacent to the position of attachment to A or B respectively;
• X is optionally substituted with 1-7 independent halogen, —CN, NO2, —C1-6alkyl, —C1-6alkenyl, —C1-6alkynyl, —OR1, —NR1R2, —C(═NR1)NR2R3, —N(═NR1)NR2R3, —NR1COR2, —NR1CO2R2, —NR1SO2R4, —NR1CONR2R3, —SR4, —SOR4, —SO2R4, —SO2NR1R2, —COR1, —CO2R1, —CONR1R2, —C(═NR1)R2, or —C(═NOR1)R2 substituents, wherein optionally two substituents are combined to form a cycloalkyl or heterocycloalkyl ring fused to X;
• wherein the —C1-6alkyl substituent, cycloalkyl ring, or heterocycloalkyl ring each optionally is further substituted with 1-5 independent halogen, —CN, —C1-6alkyl, —O(C0-6alkyl), —O(C3-7cycloalkyl), —O(aryl), —N(C0-6alkyl)(C0-6alkyl), —N(C0-6alkyl)(C3-7cycloalkyl), or —N(C0-6alkyl)(aryl) groups;
• R1, R2, and R3 each independently is —C0-6alkyl, —C3-7cycloalkyl, heteroaryl, or aryl;
• any of which is optionally substituted with 1-5 independent halogen, —CN, —C1-6alkyl, —O(C0-6alkyl), —O(C3-7cycloalkyl), —O(aryl), —N(C0-6alkyl)(C0-6alkyl), —N(C0-6alkyl)(C3-7cycloalkyl), —N(C0-6alkyl)(aryl) substituents;
• R4 is —C1-6alkyl, —C3-7cycloalkyl, heteroaryl, or aryl;
• optionally substituted with 1-5 independent halogen, —CN, —C1-6alkyl, —O(C0-6alkyl), —O(C3-7cycloalkyl), —O(aryl), —N(C0-6alkyl)(C0-6alkyl), —N(C0-6alkyl)(C3-7cycloalkyl), —N(C0-6alkyl)(aryl) substituents;
• A is —C0-4alkyl, —C0-2alkyl-SO—C0-2alkyl-, —C0-2alkyl-SO2—C0-2alkyl-, —C0-2alkyl-CO—C0-2alkyl-, —C0-2alkyl-NR9CO—C0-2alkyl-, —C0-2alkyl-NR9SO2—C0-2alkyl- or —heteroC0-4alkyl;
• W is —C3-7cycloalkyl, -heteroC3-7cycloalkyl, —C0-6alkylaryl, or —C0-6alkylheteroaryl optionally substituted with 1-7 independent halogen, —CN, NO2, —C1-6alkyl, —C1-6alkenyl, —C1-6alkynyl, —OR1, —NR1R2, —C(═NR1)NR2R3, —N(═NR1)NR2R3, —NR1COR2, —NR1CO2R2, —NR1SO2R4, —NR1CONR2R3, —SR4, —SOR4, —SO2R4, —SO2NR1R2, —COR1, —CO2R1, —CONR1R2, —C(═NR1)R2, or —C(═NOR1)R2 substituents;
• Y is optionally substituted with 1-7 independent halogen, —CN, NO2, —C1-6alkyl, —C1-6alkenyl, —C6alkynyl, —OR5, —NR5R6, —C(═NR5)NR6R7, —N(═NR5)NR6R7, —NR5COR6, —NR5CO2R6, —NR5SO2R8, —NR5CONR6R7, —SR8, —SOR8, —SO2R8, —SO2NR5R6, —COR5, —CO2R5, —CONR5R6, —C(═NR5)R6, or —C(═NOR5)R6 substituents, wherein optionally two substituents are combined to form a cycloalkyl or heterocycloalkyl ring fused to Y;
• wherein the —C1-6alkyl substituent, cycloalkyl ring, or heterocycloalkyl ring each optionally is further substituted with 1-5 independent halogen, —CN, —C1-6alkyl, —O(C0-6alkyl), —O(C3-7cycloalkyl), —O(aryl), —N(C0-6alkyl)(C0-6alkyl), —N(C0-6alkyl)(C3-7cycloalkyl), or —N(C0-6alkyl)(aryl) groups;
• R5, R6, and R7 each independently is —C0-6alkyl, —C3-7cycloalkyl, heteroaryl, or aryl;
• any of which is optionally substituted with 1-5 independent halogen, —CN, —C1-6alkyl, —O(C0-6alkyl), —O(C3-7cycloalkyl), —O(aryl), —N(C0-6alkyl)(C0-6alkyl), —N(C0-6alkyl)(C3-7cycloalkyl), —N(C0-6alkyl)(aryl) substituents;
• R8 is —C1-6alkyl, —C3-7cycloalkyl, heteroaryl, or aryl;
• optionally substituted with 1-5 independent halogen, —CN, —C1-6alkyl, —O(C0-6alkyl), —O(C3-7cycloalkyl), —O(aryl), —N(C0-6alkyl)(C0-6alkyl), —N(C0-6alkyl)(C3-7cycloalkyl), —N(C0-6alkyl)(aryl) substituents;
• B is —C0-4alkyl, —C0-2alkyl-SO—C0-2alkyl-, —C0-2alkyl-SO2—C0-2alkyl-, —C0-2alkyl-CO—C0-2alkyl-, —C0-2alkyl-NR10CO—C0-2alkyl-, —C0-2alkyl-NR10SO2—C0-2alkyl- or -heteroC0-4alkyl;
• R9 and R10 each independently is —C0-6alkyl, —C3-7cycloalkyl, heteroaryl, or aryl;
• any of which is optionally substituted with 1-5 independent halogen, —CN, —C1-6alkyl, —O(C0-6alkyl), —O(C3-7cycloalkyl), —O(aryl), —N(C0-6alkyl)(C0-6alkyl), —N(C0-6alkyl)(C3-7cycloalkyl), —N(C0-6alkyl)(aryl) substituents;
• Z is —C3-7cycloalkyl, -heteroC3-7cycloalkyl, —C0-6alkylaryl, or —C0-6alkylheteroaryl optionally substituted with 1-7 independent halogen, —CN, NO2, —C1-6alkyl, —C16alkenyl, —C1-6alkynyl, —OR1, —NR1R2, —C(═NR1)NR2R3, —N(═NR1)NR2R3, —NR1COR2, —NR1CO2R2, —NR1SO2R4, —NR1CONR2R3, —SR4, —SOR4, —SO2R4, —SO2NR1R2, —COR1, —CO2R1, —CONR1R2, —C(═NR1)R2, or —C(═NOR1)R2 substituents;
• one of W and Z is optionally absent;
• R11 and R12 is each independently halogen, —C0-6alkyl, —C0-6alkoxyl, ═O, ═N(C0-4alkyl),or —N(C0-4alkyl)(C0-4alkyl);
• and
• any alkyl optionally substituted with 1-5 independent halogen substituents, and any N may be an N-oxide.