US 2006/0217415 A1 · Novel quinuclidine derivatives and their pharmaceutical use

Abstract

This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Claims17

Dependent claims

A quinuclidine derivative represented by Formula II

wherein
represents an optional double bond;
n is 1, 2 or 3;
X represents a linker selected from —O—, —S—, —SO—, —SO2—, —CH2—, —C(═CH2)—, —NH—, —N(alkyl)-, —C(═O)—, —C(═S)—,
Y represents O, S, SO2, or NR′, wherein R′ represents hydrogen or alkyl.

2 more elements

Dependencies are inferred from the claim text.

Novel quinuclidine derivatives and their pharmaceutical use

Life of this patent

Novel quinuclidine derivatives and their pharmaceutical use

Life of this patent

Abstract

Claims17